國家衛生研究院 NHRI:Item 3990099045/2507

NHRI > National Institute of Environmental Health Sciences > Ying-Chin Ko(2003-2009) > Periodical Articles > Item 3990099045/2507

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2507

Title:	Genomewide scan for gout in Taiwanese aborigines reveals linkage to chromosome 4q25
Authors:	Cheng, LSC;Chiang, SL;Tu, HP;Chang, SJ;Wang, TN;Ko, AMJ;Chakraborty, R;Ko, YC
Contributors:	Division of Environmental Health and Occupational Medicine
Abstract:	Gout is a disorder of uric-acid metabolism. The Pacific Austronesian population, including Taiwanese aborigines, has a remarkably high prevalence of hyperuricemia and gout, which suggests a founder effect across the Pacific region. We report here a genomewide linkage study of 21 multiplex pedigrees with gout from an aboriginal tribe in Taiwan. From observations of familial clustering, early onset of gout, and clinically severe manifestations, we hypothesized that a major gene plays a role in this trait. Using 382 random polymorphic markers spread across 22 autosomes, we demonstrated a highly significant linkage for gout at marker D4S2623 on chromosome 4q25 (P=.0002 by nonparametric linkage [the NPLall statistic]; empirical;, by P=.0006; LOD=4.3, P=4.4x10(-6) by logistic regression). When alcohol consumption was included as a covariate in the model, the LOD score increased to 5.66 (P=1.3x10(-6)). Quantitative traits, including serum uric acid and creatinine, also showed a moderate linkage to this region. To our knowledge, this is the first genome-scan report to identify a genetic locus harboring a gout-susceptibility gene.
Keywords:	Genetics & Heredity
Date:	2004-09
Relation:	American Journal of Human Genetics. 2004 Sep;75(3):498-503.
Link to:	http://dx.doi.org/10.1086/423429
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0002-9297&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000223272200014
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=4344684962
Appears in Collections:	[Ying-Chin Ko(2003-2009)] Periodical Articles

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