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http://ir.nhri.org.tw/handle/3990099045/2440
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| Title: | Body burdens of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls and their relations to estrogen metabolism in pregnant women |
| Authors: | Wang, SL;Chang, YC;Chao, HR;Li, CM;Li, LA;Lin, LY;Papke, O |
| Contributors: | Division of Environmental Health and Occupational Medicine |
| Abstract: | Polychlorinated dibenzo-p-dioxins (PCDDs, dioxins), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) are environmental endocrine disruptors that have half-lives of 7-10 years in the human body and have toxicities that probably include carcinogenesis. A high ratio of 4-hydroxyl estradiol (4-OH-E-2) to 2-hydroxyl estradiol (2-OH-E-2) has been suggested as a potential biomarker for estrogen-dependent neoplasms. In this cohort study of maternal-fetal pairs, we examined the relationship of PCDD/PCDF and PCB exposure to levels of estrogen metabolites in the sera of 50 pregnant women 25-34 years of age from central Taiwan. Maternal blood was collected during the third trimester, and the placenta was collected at delivery. We measured 17 dioxin congeners, 12 dioxin-like PCBs, and 6 indicator PCBs in placenta using gas chromatography coupled with high-resolution mass spectrometry. Estrogen metabolites in maternal serum were analyzed by liquid chromatography tandem mass spectrometry. The ratio of 4-OH-E2:2-OH-E-2 decreased with increasing exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (beta = -0.124, p = 0.004 by the general linear regression model, R = 0.4). Meanwhile, serum levels of 4-OH-E2 increased with increasing concentrations of high-chlorinated PCDFs (i.e., I,2,3,4,6,7,8-hepta-CDF: P = 0.454, p = 0.03, R = 0.30). Altered estrogen catabolism might be associated with body burdens of PCDDs/PCDFs. Our study suggests that exposure to PCDDs/PCDFs significantly affects estrogen metabolism. Therefore, PCDD/PCDF exposure must be considered when using the OH-E-2 ratio as a breast cancer marker. |
| Keywords: | Environmental Sciences;Public, Environmental & Occupational Health |
| Date: | 2006-05 |
| Relation: | Environmental Health Perspectives. 2006 May;114(5):740-745. |
| Link to: | http://dx.doi.org/10.1289/ehp.8809 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0091-6765&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000237308500043 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33646368663 |
| Appears in Collections: | [李立安] 期刊論文
[張玉珍(2000-2003)] 期刊論文
[王淑麗] 期刊論文
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| 000237308500043.pdf | | 190Kb | Adobe PDF | 892 | View/Open |
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