國家衛生研究院 NHRI:Item 3990099045/2421
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    題名: Two-sample scale tests for comparison of metabolic rates for styrene in previously exposed and unexposed groups
    作者: Chen, CC;Wu, KY;Balakrishnan, N
    貢獻者: Division of Environmental Health and Occupational Medicine
    摘要: Statistical analysis procedure in two-sample treatment difference, as well as alternative hypothesis, may play a central role in statistical inference, especially in small sample size case. In this paper, simple non-parametric two-sample permutation tests for scale difference based on the Hodges-Lehmann estimator are reformulated, and are applied to a study examining whether previous styrene exposure increases (thus a one-sided alternative hypothesis rather than a two-sided one) the human liver's metabolic ability to convert styrene into styrene oxide, in which a three-compartment physiologically based pharmacokinetic (PBPK) model was used to compare the estimated metabolic constant K among the previously exposed and unexposed groups. Contrary to the previous conclusion, the proposed tests for scale difference identified from a mixed-effects model showed a significant result.
    關鍵詞: Mathematical & Computational Biology;Public, Environmental & Occupational Health;Medical Informatics;Medicine, Research & Experimental;Statistics & Probability
    日期: 2004-02-28
    關聯: Statistics in Medicine. 2004 Feb;23(4):591-599.
    Link to: http://dx.doi.org/10.1002/sim.1617
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0277-6715&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000188737900005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=1142263237
    顯示於類別:[吳焜裕(2001-2008)] 期刊論文

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