國家衛生研究院 NHRI:Item 3990099045/2408
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 907126      在线人数 : 870
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/2408


    题名: Sperm DNA damage correlates with polycyclic aromatic hydrocarbons biomarker in coke-oven workers
    作者: Hsu, PC;Chen, IY;Pan, CH;Wu, KY;Pan, MH;Chen, JR;Chen, CJ;Chang-Chien, GP;Hsu, CH;Liu, CS;Wu, MT
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: Objectives: The aim was to determine whether occupational exposure to polycyclic aromatic hydrocarbons (PAHs) in men has adverse effect on semen quality. Methods: Forty-eight coke-oven workers, including 16 topside-oven (TO) workers and 32 sideoven (SO) workers, were studied. Ambient PAHs exposure, urinary 1-hydroxypyrene (1-OHP) levels, and parameters of semen quality were determined. Results: TO workers had significantly higher ambient PAHs exposure (3,436.1 +/- 3,411.0 vs. 1,123.1 +/- 1,829.3 ng/m(3), P < 0.01), urinary 1-OHP levels (207.8 +/- 176.4 vs. 54.0 +/- 44.8 mu g/g, P < 0.001), frequency of oligospermia (18.8 vs. 0%, P < 0.05), and morphological abnormality in sperm (32.3 vs. 14.6%, P < 0.01) than SO workers. Among cigarette smokers, TO workers had significantly higher rates of DNA denaturation in spermatozoa (alpha T) and percentage of sperm with increased DNA denaturation (COMP alpha T) levels than SO workers (246.2 +/- 49.5 vs. 198.1 +/- 30.3 for alpha T; 34.8 +/- 14.4 vs. 19.3 +/- 13.9% for COMP alpha T, P < 0.05). There was a positive correlation between urinary 1-OHP and alpha T, COMP alpha T, and abnormal sperm morphology and a tenfold increase in urinary 1-OHP associated with a 2.35-fold increase in alpha T, as well as a 1.07-fold increase in percentage of sperm with abnormal morphology. Conclusions: A potential risk of sperm dysfunction should be considered for workers occupationally exposed to high levels of PAHs. Cigarette smoking may aggravate this risk. Urinary 1-OHP can be used as a biomarker predicting sperm dysfunction.
    关键词: Public, Environmental & Occupational Health
    日期: 2006-05
    關聯: International Archives of Occupational and Environmental Health. 2006 May;79(5):349-356.
    Link to: http://dx.doi.org/10.1007/s00420-005-0066-3
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0340-0131&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000236355600002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33645168089
    显示于类别:[吳焜裕(2001-2008)] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    000236355600002.pdf250KbAdobe PDF993检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈