國家衛生研究院 NHRI:Item 3990099045/2407
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    题名: Analysis of 7-methylguanine using isotope dilution and gas chromatography/electron-capture negative chemical ionization mass spectrometry
    作者: Chiang, SY;Huang, TH;Uang, SN;Wu, HDI;Wei, YC;Lin, HY;Swenberg, JA;Wu, KY
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: This paper presents results obtained for in vivo endogenous and exogenous 7-methylguanine (7-MG) analyzed using a method incorporating gas chromatography with electron-capture negative chemical ionization mass spectrometry and isotope dilution (GC/EC-ID-MS). C-13(4)-Labeled 7-MG was synthesized to serve as an internal standard to improve accuracy of quantitation, and was used to analyze 7-MG in livers of control mice and dacarbazine-treated mice. The results confirm that 7-MG in tissue DNA can be measured using this GC/EC-ID-MS method with excellent sensitivity and specificity. Administration of 0, 30, and 60mg/kg dacarbazine to mice led to dose-dependent increases in the formation of 7-MG. The results indicate that this method could be applied to the analysis of endogenous and exogenous 7-MG in human tissues for future molecular epidemiology studies on potential health effects caused by methylating agents.
    关键词: Chemistry, Analytical;Spectroscopy
    日期: 2005
    關聯: Rapid Communications in Mass Spectrometry. 2005;19(14):1915-1920.
    Link to: http://dx.doi.org/10.1002/rcm.2003
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0951-4198&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000230666700001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=22744455329
    显示于类别:[吳焜裕(2001-2008)] 期刊論文

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