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Institute of Biotechnology and Pharmaceutical Research
Su-Ying Wu
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Kak-Shan Shia
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Chung-Ming Chang
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Jang-Yang Chang
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John Tsu-An Hsu
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Shiow-Ju Lee
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Jinq-Chyi Lee
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Shu-Yu Lin
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Ming-Shiu Hung
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Shiow-Lin Pan(2009-2013)
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Wen-Chieh Wang
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Hung-Jung Wang
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Chuan Shih(2014-2017)
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Chun-Wei Tung
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Ya-Hui Chi
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Shau-Hua Ueng
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Hong Zhuang
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Shiu-Hwa Yeh
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Weir-Torn Jiaang
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Hsing-Pang Hsieh
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Yu-Sheng Chao(2002-2013)
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Ching-Chuan Kuo
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Lun Kelvin Tsou
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Jyh-Haur Chern
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Xin Chen(2002-2015)
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Chiung-Tong Chen
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Wan-Ching Yen
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Ming-Chu Hsu(1997-2001)
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Shu-Jung Chen(1998-2001)
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Hua-Chien Chen(1997-2001)
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Date
Title
Relation
2022-02-05
Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design
European Journal of Medicinal Chemistry. 2022 Feb 5;229:Article number 114043.
2021-08-12
Xanthine derivatives reveal an allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2)
Journal of Medicinal Chemistry. 2021 Aug 12;64(15):11288-11301.
2020-02-10
Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors
Journal of Medicinal Chemistry. 2020 Feb 10;63(4):1642-1659.
2019-12
Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia
Journal of Medicinal Chemistry. 2019 Dec;62(24):11135-11150.
2019-11-27
Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer
Journal of Medicinal Chemistry. 2019 Nov 27;62(22):10108-10123.
2019-10
Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer
Annals of Oncology. 2019 Oct;30(Suppl. 5):789.
2019-04-10
Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants
Journal of Medicinal Chemistry. 2019 Apr 10;62(8):3940-3957.
2018-04
4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy
Bioorganic Chemistry. 2018 Apr;77:600-607.
2017-06
Mutagenesis of dengue virus protein NS2A revealed a novel domain responsible for virus-induced cytopathic effect and interactions between NS2A and NS2B transmembrane segments
Journal of Virology. 2017 Jun;91(12):Article number e01836-16.
2016-12
Phenyl benzenesulfonylhydrazides: Selective indoleamine 2,3-dioxygenase inhibitors with potent in vivo pharmacodynamic activity and antitumor efficacy
European Journal of Cancer. 2016 Dec;68(Suppl. 1):S83-S84.
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