國家衛生研究院 NHRI:Item 3990099045/2394

NHRI > National Institute of Environmental Health Sciences > Ming-Tsang Wu(2000-2001) > Periodical Articles > Item 3990099045/2394

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2394

Title:	Genetic polymorphisms of p53 and GSTP1, but not NAT2, are associated with susceptibility to squamous-cell carcinoma of the esophagus
Authors:	Lee, JM;Lee, YC;Yang, SY;Shi, WL;Lee, CJ;Luh, SP;Chen, CJ;Hsieh, CY;Wu, MT
Contributors:	Division of Environmental Health and Occupational Medicine
Abstract:	The interaction of genetic and environmental factors can determine an individual's susceptibility to various cancers. We present a hospital-based case-control study, which included 90 patients of esophageal squamous-cell carcinoma (ESCC) and 254 healthy people in Taiwan, to investigate the effects of genetic polymorphisms of p53, GSTP1 and NAT2 on the risk of ESCC, Polymorphisms of p53, NAT2 and GSTP1 were determined by PCR-RFLP. The codon 72 p53 pro allele was more frequently found in ESCC patients [odds ratio (OR) 1.86, 95% confidence interval (CI) 1.04-3.35 for Arg/Pro genotype and OR 2.56, 95% CI 1.29-5.08 for Pro/Pro genotype], In cigarette smokers, the frequency of GSTP1 Ile/Ile genotype was higher in ESCC patients (OR 2.8, 95% CI 1.4-5.7), Among alcohol drinkers, borderline significance was also found for GSTP1 Ile/Ile genotype (OR 2.0, 95% CI 0.9-4.4), Results were not similar for the NAT2 genetic polymorphism. Using logistic analyses, we found that individuals with p53 Pro/Pro genotype had a significantly higher risk of developing ESCC than those with Arg/Arg genotype (OR 2.3, 95% CI 1.1-5.1), after adjusting for other significant environmental risk factors. This result remained similar (OR 2.2, 95% CI 1.0-4.8 for p53 Pro/Pro vs. Arg/Arg), even after further adjustment for NAT2 and GSTP1 polymorphisms. The codon 72 p53 Pro/Pro genotype in the general population and GSTP1 Ilellle in cigarette smokers may predict a higher risk of developing ESCC. (C) 2000 Wiley-Liss. Inc.
Keywords:	Oncology
Date:	2000-09-20
Relation:	International Journal of Cancer. 2000 Sep;89(5):458-464.
Link to:	http://www3.interscience.wiley.com/journal/73501486/abstract
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0020-7136&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000089667200010
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033797888
Appears in Collections:	[Ming-Tsang Wu(2000-2001)] Periodical Articles

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