國家衛生研究院 NHRI:Item 3990099045/2363
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2363


    Title: Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells
    Authors: Qiu, Y;Ravi, L;Kung, HJ
    Contributors: Division of Molecular and Genomic Medicine
    Abstract: Interleukin-6 (IL-6) is a cytokine that was initially recognized as a regulator of immune and inflammatory responses(1), but it also regulates the growth of many tumour cells, including prostrate carcinoma(2-4). Overexpression of the growth-factor receptors ErbB2/neu and ErbB3 has been implicated in the neoplastic transformation of prostate carcinoma(5-7). Here we show that treatment of the prostate cancer cell line LNCaP with IL-6 induces tyrosine phosphorylation of ErbB2 and ErbB3, but not ErbB1/ EGFR. We also show that ErbB2 forms a complex with the gp130 subunit of the IL-6 receptor in an IL-6-dependent manner. This association is important because the inhibition of ErbB2 activity results in abrogation of IL-6-induced MAPK activation. Thus ErbB2 is a critical component of IL-6 signalling through the MAP kinase pathway. These data show how a cytokine receptor can diversify its signalling pathways by engaging with a growth-factor receptor kinase.
    Keywords: Multidisciplinary Sciences
    Date: 1998-05-07
    Relation: Nature. 1998 May;393(6680):83-85.
    Link to: http://dx.doi.org/10.1038/30012
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0028-0836&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000073497500052
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0032492879
    Appears in Collections:[Hsing-Jien Kung] Periodical Articles

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