國家衛生研究院 NHRI:Item 3990099045/2343
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    題名: Description of the transcriptomes of immune response-activated Hemocytes from the mosquito vectors Aedes aegypti and Armigeres subalbatus
    作者: Bartholomay, LC;Cho, WL;Rocheleau, TA;Boyle, JP;Beck, ET;Fuchs, JF;Liss, P;Rusch, M;Butler, KM;Wu, RCC;Lin, SP;Kuo, FY;Tsao, IY;Huang, CY;Liu, TT;Hsiao, KJ;Tsai, SF;Yang, UC;Nappi, AJ;Perna, NT;Chen, CC;Christensen, BM
    貢獻者: Division of Molecular and Genomic Medicine
    摘要: Mosquito-borne diseases, including dengue, malaria, and lymphatic filariasis, exact a devastating toll on global health and economics, killing or debilitating millions every year (54). Mosquito innate immune responses are at the forefront of concerted research efforts aimed at defining potential target genes that could be manipulated to engineer pathogen resistance in vector populations. We aimed to describe the pivotal role that circulating blood cells (called hemocytes) play in immunity by generating a total of 11,952 Aedes aegypti and 12,790 Armigeres subalbatus expressed sequence tag (EST) sequences from immune response-activated hemocyte libraries. These ESTs collapsed into 2,686 and 2,11[07 EST clusters, respectively. The clusters were used to adapt the web-based interface for annotating bacterial genomes called A Systematic Annotation Package for Community Analysis of Genomes (ASAP) for analysis of ESTs. Each cluster was categorically characterized and annotated in ASAP based on sequence similarity to five sequence databases. The sequence data and annotations can be viewed in ASAP at https://asap.ahabs.wisc.edu/annotation/php/ASAP1.htm. The data presented here represent the results of the first high-throughput in vivo analysis of the transcriptome of immunocytes from an invertebrate. Among the sequences are those for numerous immunity-related genes, many of which parallel those employed in vertebrate innate immunity, that have never been described for these mosquitoes.
    關鍵詞: Immunology;Infectious Diseases
    日期: 2004-07
    關聯: Infection and Immunity. 2004 Jul;72(7):4114-4126.
    Link to: http://dx.doi.org/10.1128/IAI.72.7.4114-4126.2004
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0019-9567&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000222282800049
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=3042641031
    顯示於類別:[蔡世峯] 期刊論文

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