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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/2326
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| Title: | DNA sequence and comparative analysis of chimpanzee chromosome 22 |
| Authors: | Watanabe, H;Fujiyama, A;Hattori, M;Taylor, TD;Toyoda, A;Kuroki, Y;Noguchi, H;BenKahla, A;Lehrach, H;Sudbrak, R;Kube, M;Taenzer, S;Galgoczy, P;Platzer, M;Scharfe, M;Nordsiek, G;Blocker, HB;Hellmann, I;Khaitovich, P;Paabo, S;Reinhardt, R;Zheng, HJ;Zhang, XL;Zhu, GF;Wang, BF;Fu, G;Ren, SX;Zhao, GP;Chen, Z;Lee, YS;Cheong, JE;Choi, SH;Wu, KM;Liu, TT;Hsiao, KJ;Tsai, SF;Kim, CG;Oota, S;Kitano, T;Kohara, Y;Saitou, N;Park, HS;Wang, SY;Yaspo, ML;Sakaki, Y |
| Contributors: | Division of Molecular and Genomic Medicine |
| Abstract: | Human-chimpanzee comparative genome research is essential for narrowing down genetic changes involved in the acquisition of unique human features, such as highly developed cognitive functions, bipedalism or the use of complex language. Here, we report the high-quality DNA sequence of 33.3 megabases of chimpanzee chromosome 22. By comparing the whole sequence with the human counterpart, chromosome 21, we found that 1.44% of the chromosome consists of single-base substitutions in addition to nearly 68,000 insertions or deletions. These differences are sufficient to generate changes in most of the proteins. Indeed, 83% of the 231 coding sequences, including functionally important genes, show differences at the amino acid sequence level. Furthermore, we demonstrate different expansion of particular subfamilies of retrotransposons between the lineages, suggesting different impacts of retrotranspositions on human and chimpanzee evolution. The genomic changes after speciation and their biological consequences seem more complex than originally hypothesized. |
| Keywords: | Multidisciplinary Sciences |
| Date: | 2004-05-27 |
| Relation: | Nature. 2004 May;429(6990):382-388. |
| Link to: | http://dx.doi.org/10.1038/nature02564 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0028-0836&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000221644600031 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=2642575083 |
| Appears in Collections: | [蔡世峯] 期刊論文
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| 000221644600031.pdf | | 543Kb | Adobe PDF | 760 | View/Open |
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