國家衛生研究院 NHRI:Item 3990099045/2269
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    题名: Identification of the substrates and interaction proteins of Aurora kinases from a protein-protein interaction model
    作者: Tien, AC;Lin, MH;Su, LJ;Hong, YR;Cheng, TS;Lee, YCG;Lin, WJ;Still, IH;Huang, CYF
    贡献者: Division of Molecular and Genomic Medicine
    摘要: The increasing use of high-throughput and large-scale bioinformatics-based studies has generated a massive amount of data stored in a number of different databases. The major need now is to explore this disparate data to find biologically relevant interactions and pathways. Thus, in the post-genomic era, there is clearly a need for the development of algorithms that can accurately predict novel protein-protein interaction networks in silico. The evolutionarily conserved Aurora family kinases have been chosen as a model for the development of a method to identify novel biological networks by a comparison of human and various model organisms. Our search methodology was designed to predict and prioritize molecular targets for Aurora family kinases, so that only the most promising are subjected to empirical testing. Four potential Aurora substrates and/or interacting proteins, TACC3, survivin, Hec1, and hsNuf2, were identified and empirically validated. Together, these results justify the timely implementation of in silico biology in routine wet-lab studies and have also allowed the application of a new approach to the elucidation of protein function in the postgenomic era.
    关键词: Biochemical Research Methods
    日期: 2004-01
    關聯: Molecular and Cellular Proteomics. 2004 Jan;3(1):93-104.
    Link to: http://dx.doi.org/10.1074/mcp.M300072-MCP200
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1535-9484&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000188432800009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=2442660142
    显示于类别:[黃奇英(1998-2005)] 期刊論文

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