國家衛生研究院 NHRI:Item 3990099045/2215
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    题名: Temporal transcription program of recombinant Autographa californica multiple nucleopolyhedrosis virus
    作者: Jiang, SS;Chang, IS;Huang, LW;Chen, PC;Wen, CC;Liu, SC;Chien, LC;Lin, CY;Hsiung, CA;Juang, JL
    贡献者: Division of Molecular and Genomic Medicine;Division of Biostatistics and Bioinformatics;National Institute of Cancer Research
    摘要: Baculoviruses, a family of large, rod-shaped viruses that mainly infect lepidopteran insects, have been widely used to transduce various cells for exogenous gene expression. Nonetheless, how a virus controls its transcription program in cells is poorly understood. With a custom-made baculovirus DNA microarray, we investigated the recombinant Autagrapha californica multiple nucleopolyhedrosis virus (AcMNPV) gene expression program in lepidopteran Sf21 cells over the time course of infection. Our analysis of transcription kinetics in the cells uncovered sequential viral gene expression patterns possibly regulated by different mechanisms during different phases of infection. To gain further insight into the regulatory network, we investigated the transcription program of a mutant virus deficient in an early transactivator (pe38) and uncovered several pe38-dependent and pe38-independent genes. This study of baculovirus dynamic transcription programs in different virus genetic backgrounds provides new molecular insights into how gene expression in viruses is regulated.
    关键词: Virology
    日期: 2006-09
    關聯: Journal of Virology. 2006 Sep;80(18):8989-8999.
    Link to: http://dx.doi.org/10.1128/JVI.01158-06
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-538X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000240384800015
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33748490905
    显示于类别:[莊志立] 期刊論文
    [林仲彥(1999-2005)] 期刊論文
    [熊昭] 期刊論文
    [張憶壽] 期刊論文
    [江士昇] 期刊論文

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