國家衛生研究院 NHRI:Item 3990099045/2213
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2213


    Title: Distinct translation regulation by two alternative 5 ' UTRs of a stress-responsive protein - dPrx I
    Authors: Chen, CW;Lin, TY;Chen, TC;Juang, JL
    Contributors: Division of Molecular and Genomic Medicine
    Abstract: Translation efficiency is often regulated in part by 5'-untranslated region (5'UTR). Sequence analysis of an evolutionarily conserved stress-responsive protein, Drosophila Peroxiredoxin I (dPrx I), found the transcript to have two alternative 5'UTRs that lead to an identical coding sequence: namely Ia and Ib. Although both isoforms coexisted in Drosophila cells, the Ia isoform appeared to be dominant. Furthermore, reporter assay found that Ia enhanced translation in steady-state cells while Ib increased translation in cells under oxidative stress. Together, our data suggest that the two alternative 5'UTRs of dPrx I may be involved in a translational regulatory mechanism that responds to cellular oxidative stress.
    Keywords: Medicine, Research & Experimental
    Date: 2005-10
    Relation: Journal of Biomedical Science. 2005 Oct;12(5):729-739.
    Link to: http://dx.doi.org/10.1007/s11373-005-9013-2
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1021-7770&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000233238400004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=27744493509
    Appears in Collections:[Jyh-Lyh Juang] Periodical Articles

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