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Activation of NRF2/ABCC1 axis confers resistance to topoisomerase II poisons in human oral malignancies |
Cancer Research. 2011 Apr;71:Abstract number 1528. |
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MPT0B098, a novel microtubule inhibitor, displays potent anti-angiogenic activity via destabilizing hypoxia-inducible factor-1alpha mRNA |
Cancer Research. 2011 Apr;71(Suppl. 8):Meeting Abstract 4461. |
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| 2011-04 |
Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway |
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| 2011-03-07 |
Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents |
Molecules. 2011 Mar 7;16(3):2274-2284. |
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2-Amino-3,4,5-Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors |
ChemMedChem. 2011 Mar 7;6(3):450-456. |
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| 2011-01-26 |
Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana |
Tetrahedron Letters. 2011 Jan 26;52(4):515-517. |
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BPR0C261 is a novel orally active antitumor agent with antimitotic and anti-angiogenic activities |
Cancer Science. 2011 Jan;102(1):182-191. |
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| 2011-01 |
Investigations of survivin: the past, present and future |
Frontiers in Bioscience. 2011 Jan;16:952-961. |
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| 2010-12 |
Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: a biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells |
Molecular Cancer. 2010 Dec;9:Article number 309 |
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| 2010-10 |
MBP-1 is efficiently encoded by an alternative transcript of the ENO1 gene but post-translationally regulated by proteasome-dependent protein turnover |
FEBS Journal. 2010 Oct;277(20):4308-4231. |
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Combined modalities of resistance in a cisplatin-driven human betel-associated oral squamous cell carcinoma |
Annals of Oncology. 2010 Oct;21(Suppl. 8):52. |
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| 2010-09 |
Cancer cells acquire mitotic drug resistance properties through beta i-tubulin mutations and alterations in the expression of beta-tubulin isotypes |
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Synthesis and biological evaluation of 7-arylindoline-1-benzenesulfonamides as a novel class of potent anticancer agents |
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| 2010-06-18 |
Cytotoxic C35 terpenoid cryptotrione from the bark of cryptomeria japonica |
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Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis |
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Randomized, phase 1 study of everolimus in patients with advanced hepatocellular carcinoma |
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Chamaecypanone C, a novel skeleton microtubule inhibitor, with anticancer activity by trigger caspase 8-Fas/FasL dependent apoptotic pathway in human cancer cells |
Biochemical Pharmacology. 2010 May;79(9):1261-1271. |
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Recent advances in anti-survivin treatments for cancer |
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Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells |
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Arecoline arrests cells at prometaphase by deregulating mitotic spindle assembly and spindle assembly checkpoint: Implication for carcinogenesis |
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5-Amino-2-Aroylquinolines as Highly Potent Tubulin Polymerization Inhibitors |
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| 2010-03 |
Paclitaxel and carboplatin-induced complete remission in peritoneal carcinomatosis of unknown origin: A report of two cases and review of the literature |
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| 2009-12 |
Alpha-fetoprotein response in advanced hepatocellular carcinoma receiving cytostatic agent |
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| 2009-09 |
Synergistic augmentation of arsenic trioxide-induced cytotoxicity by BCNU through reactive oxygen species-related autophagic pathway in human solid tumors |
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Synthesis and evaluation of 3-aroylindoles as anticancer agents: Metabolite approach |
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| 2009-07-23 |
Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity |
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| 2009-07-03 |
Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers |
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Randomized, phase I, and pharmacokinetic (PK) study of RAD001, an mTOR inhibitor, in patients (pts) with advanced hepatocellular carcinoma (HCC) |
Journal of Clinical Oncology. 2009 May 20;27(15s):Abstract number 4587. |
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Down-regulation of survivin enhances sensitivity to BPROL075 in human cancer cells via caspase-independent mechanisms |
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| 2009-04-17 |
Synthesis and structure-activity relationships of 1-benzyl-4,5,6-trimethoxyindoles as a novel class of potent antimitotic agents |
ChemMedChem. 2009 Apr 17;4(4):588-593. |
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| 2009-04 |
Aurora kinase inhibitors in preclinical and clinical testing |
Expert Opinion on Investigational Drugs. 2009 Apr;18(4):379-398. |
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Increasing incidence of intrahepatic cholangiocarcinoma and its relationship to chronic viral hepatitis |
Journal of the National Comprehensive Cancer Network. 2009 Apr;7(4):423-427. |
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Advances in Aurora kinase inhibitor patents |
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| 2008-12-25 |
Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents |
Journal of Medicinal Chemistry. 2008 Dec 25;51(24):8163-8167. |
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| 2008-11-25 |
Anti-tumor compounds |
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| 2008-10-28 |
Human DNA polymerase eta activity and translocation is regulated by phosphorylation |
Proceedings of the National Academy of Sciences of the United States of America. 2008 Oct 28;105(43):16578-16583. |
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| 2008-10 |
Modern staging and utility of PET imaging in esophageal cancer management |
Journal of the National Comprehensive Cancer Network. 2008 Oct;6(9):862-869. |
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| 2008-08 |
Transcriptional repression of O-6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N '-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells |
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| 2008-07-24 |
Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors |
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A novel peroxisome proliferator-activated receptor alpha/gamma agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells |
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| 2007-11-15 |
Tamoxifen accelerates proteasomal degradation of O-6-methylguanine DNA methyltransferase in human cancer cells |
International Journal of Cancer. 2007 Nov;121(10):2293-2300. |
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| 2007-10 |
A novel oral indoline-sulfonamide agent, N-[1-(4-Methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-yl]-Isonicotinamide (J30), exhibits potent activity against human cancer cells in vitro and in vivo through the disruption of microtubule |
Journal of Pharmacology and Experimental Therapeutics. 2007 Oct;323(1):398-405. |
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Human tissue kallikreins as prognostic biomarkers and as potential targets for anticancer therapy |
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| 2007-09-06 |
4-and 5-aroylindoles as novel classes of potent antitubulin agents |
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