國家衛生研究院 NHRI:Item 3990099045/2158
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    题名: SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx
    作者: Kuo, HY;Chang, CC;Jeng, JC;Hu, HM;Lin, DY;Maul, GG;Kwok, RPS;Shih, HM
    贡献者: Division of Molecular and Genomic Medicine
    摘要: Small ubiquitin-like modifier (SUMO) modification is emerging as an important control in transcription regulation. Here, we show that CREB-binding protein (CBP), a versatile transcriptional coactivator for numerous transcription factors in response to diverse signaling events, can be modified by SUMO-1 at lysine residues 999, 1034, and 1057 both in vitro and in vivo. Mutation of the SUMO acceptor lysine residues either individually or in combination enhanced CBP transcriptional activity, and expression of a SUMO protease SENP2 potentiated the transcriptional activity of CBP wild-type but not its sumoylation mutant, indicating that SUMO modification negatively regulates CBP transcriptional activity. Furthermore, we demonstrated an interaction of SUMO-1-modified CBP with the transcriptional corepressor Daxx and an essential role of Daxx in mediating SUMO-dependent transcriptional regulation of CBP through histone deacetylase 2 recruitment. Together, our findings indicate that SUMO modification and subsequent recruitment of Daxx represent a previously undescribed mechanism in modulating CBP transcriptional potential.
    关键词: Multidisciplinary Sciences
    日期: 2005-11-22
    關聯: Proceedings of the National Academy of Sciences of the United States of America. 2005 Nov;102(47):16973-16978.
    Link to: http://dx.doi.org/10.1073/pnas.0504460102
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0027-8424&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000233463200014
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=28044437730
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