國家衛生研究院 NHRI:Item 3990099045/2140

NHRI > Institute of Molecular and Genomic Medicine > Yuh-Shan Jou(1996-2005) > Periodical Articles > Item 3990099045/2140

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Title:	Frequent allelic deletion at the FHIT locus associated with p53 overexpression in squamous cell carcinoma subtype of Taiwanese non-small-cell lung cancers
Authors:	Lee, YC;Wu, CT;Shih, JY;Jou, YS;Chang, YL
Contributors:	Division of Molecular and Genomic Medicine
Abstract:	The fragile histidine triad (FHIT) gene, encompassing the FRA3B fragile site at chromosome 3p14.2, is a tumour suppressor gene involved in different tumour types including non-small-cell lung cancers (NSCLCs). In the current study, we examined for allelic deletion at the FHIT locus in 58 primary and microdissected NSCLCs, for which a clinicopathologic profile was available. We found a loss of 87.7% in heterozygosity (LOH) frequency at one or more microsatellite markers (D3S1289, D3S2408, D3S1766, D3S1312, D3S1600). Allelic deletion of D3S1766 was related to tumour histology in 10 of 11 squamous cell carcinomas (90.9%) displaying LOH compared with nine of 17 adenocarcinomas (52.9%; P = 0.049). Besides, in the subset of adenocarcinomas, a higher rate of LOH at D3S1289 was observed in male ( six out of eight, 75%) than in female patients (four out of 17, 23.5%; P = 0.028). However, FHIT LOH was not correlated overall with a variety of clinical parameters including sex, smoking status, staging, lymph node metastasis and survival. These results indicated that the high frequency of FHIT gene disruption was important in the development of both squamous cell carcinomas and adenocarcinomas. Furthermore, there was no association between LOH at FHIT and protein expression, suggesting the presence of complex mechanisms of Fhit inactivation. On the other hand, the association between FHIT LOH and p53 protein overexpression assessment reached statistical significance ( P = 0.026), implying that common alterations affect the two genes in tumour progression.
Keywords:	Oncology
Date:	2004-06-14
Relation:	British Journal of Cancer. 2004 Jun;90(12):2378-2383.
Link to:	http://dx.doi.org/10.1038/sj.bjc.6601778
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0007-0920&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000222427100019
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=3042743715
Appears in Collections:	[Yuh-Shan Jou(1996-2005)] Periodical Articles

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