國家衛生研究院 NHRI:Item 3990099045/2126
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    題名: Transcriptome of Escherichia coli K1 bound to human brain microvascular endothelial cells
    其他題名: Transcriptome of Escherichia coli K1 bound to human brain microvascular endothelial cells
    作者: Xie, Y;Parthasarathy, G;Di Cello, F;Teng, CH;Paul-Satyaseela, M;Kim, KS
    貢獻者: Division of Clinical Research
    摘要: Escherichia coli K1 is the most common Gram-negative organism causing neonatal meningitis. Binding to human brain microvascular endothelial cells (HBMEC) is an essential step for E. coli K1 traversal of the blood-brain barrier. In this study, we examined expression profiles of E. coli K1 strain RS218 during its binding to HBMEC. Comparison of HBMEC-bound E. coli K1 with collagen-bound E. coli revealed more than one hundred genes whose expression patterns were significantly changed in HBMEC-bound E coli K1, but not in collagen-bound E. coli K L These genes are involved mainly in cell surface decorations, cellular function, and nitrogen metabolism. The roles of several representative genes including frdA, clpB, carA, and ompT in HBMEC binding were verified with their isogenic mutants, which exhibited significantly less HBMEC binding capability compared to that of the parent strain. This transcriptome analysis provided us with the first genomic-level view of E. coli and HBMEC interactions.
    關鍵詞: Biochemistry & Molecular Biology;Biophysics
    日期: 2008-01-04
    關聯: Biochemical and Biophysical Research Communications. 2008 Jan;365(1):201-206.
    Link to: http://dx.doi.org/10.1016/j.bbrc.2007.10.174
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0006-291X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000251493900033
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=36049016402
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