國家衛生研究院 NHRI:Item 3990099045/2110

NHRI > National Institute of Infectious Diseases and Vaccinology > Ih-Jen Su(2002-2015) > Periodical Articles > Item 3990099045/2110

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2110

Title:	Neutralizing antibody response and SARS severity
Authors:	Ho, MS;Chen, WJ;Chen, HY;Lin, SF;Wang, MC;Di, JL;Lu, YT;Liu, CL;Chang, SC;Chao, CL;Chao, CL;King, CC;Chiou, JM;Su, IJ;Yang, JY
Contributors:	Division of Clinical Research
Abstract:	Using the Taiwan nationwide laboratory-confirmed severe acute respiratory syndrome (SARS) database, we analyzed neutralizing antibody in relation to clinical outcomes. With a linear mixed model, neutralizing antibody titer was shown to peak between week 5 and week 8 after onset and to decline thereafter, with a half-life of 6.4 weeks. Patients with a longer illness showed a lower neutralizing antibody response than patients with a shorter illness duration (p = 0.008). When early responders were compared with most patients, who seroconverted on and after week 3 of illness, the small proportion (17.4%) of early responders (antibody detectable within 2 weeks) had a higher death rate (29.6% vs. 7.8%) (Fisher exact test, p = 0.004), had a shorter survival time of < 2 weeks (Fisher exact test, p = 0.013), and were more likely to be > 60 years of age (Fisher exact test, p = 0.01). Our findings have implications for understanding the pathogenesis of SARS and for SARS vaccine research and development.
Keywords:	Immunology;Infectious Diseases
Date:	2005-11
Relation:	Emerging Infectious Diseases. 2005 Nov;11(11):1730-1737.
Link to:	http://www.cdc.gov/ncidod/EID/vol11no11/04-0659.htm
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1080-6040&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000233076300011
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=27744442004
Appears in Collections:	[Ih-Jen Su(2002-2015)] Periodical Articles

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