國家衛生研究院 NHRI:Item 3990099045/2096

NHRI > National Institute of Infectious Diseases and Vaccinology > Ih-Jen Su(2002-2015) > Conference Papers/Meeting Abstract > Item 3990099045/2096

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2096

Title:	An interferon-gamma-related cytokine storm in SARS patients
Authors:	Huang, KJ;Su, IJ;Theron, M;Wu, YC;Lai, SK;Liu, CC;Lei, HY
Contributors:	Division of Clinical Research
Abstract:	Fourteen cytokines or chemokines were analyzed on 88 RT-PCR-confirmed severe acute respiratory syndrome (SARS) patients. IFN-gamma, IL-18, TGF-beta, IL-6, IP-10, MCP-1, MIG, and IL-8, but not of TNF-alpha, IL-2, IL-4, IL-10, IL-13, or TNFRI, were highly elevated in the acute phase sera of Taiwan SARS patients. IFN-gamma was significantly higher in the Ab(+) group than in the Ab(-) group. IFN-gamma, IL-18, MCP-1, MIG, and IP-10 were already elevated at early days post fever onset. Furthermore, levels of IL-18, IP-10, MIG, and MCP-1 were significantly higher in the death group than in the survival group. For the survival group, IFN-gamma and MCP-1 were inversely associated with circulating lymphocytes count and monocytes count, but positively associated with circulating neutrophils count. It is concluded that an interferon-gamma-related cytokine storm was induced post SARS coronavirus infection, and this cytokine storm might be involved in the immunopathological damage in SARS patients. (C) 2004 Wiley-Liss, Inc.
Keywords:	Virology
Date:	2005-02
Relation:	Journal of Medical Virology. 2005 Feb;75(2):185-194.
Link to:	http://dx.doi.org/10.1002/jmv.20255
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0146-6615&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000226009400002
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=11144224478
Appears in Collections:	[Ih-Jen Su(2002-2015)] Conference Papers/Meeting Abstract

Files in This Item:

File	Description	Size	Format
000226009400002.pdf		145Kb	Adobe PDF	873	View/Open

Loading...