國家衛生研究院 NHRI:Item 3990099045/2052
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    题名: Non-lethal Candida albicans cph1/cph1 efg1/efg1 transcription factor mutant establishing restricted zone of infection in a mouse model of systemic infection
    作者: Chen, CG;Yang, YL;Cheng, HH;Su, CL;Huang, SF;Chen, CT;Liu, YT;Su, IJ;Lo, HJ
    贡献者: Division of Clinical Research;Division of Biotechnology and Pharmaceutical Research;Division of Molecular and Genomic Medicine
    摘要: The cph1/cph1 efg1/efg1andida albicans mutant cells were non-lethal in a mouse model of systemic infection. We investigated in vivo proliferation and invasion of C albicans cells in infected mice to elucidate the interaction between the host and the pathogen. Homogenates of kidneys from the mice infected with the wild-type and the mutant C albicans cells yielded a mean of 2.1 x 10(7)CFU/g and 2.2 x 10(6) CFU/g, respectively. The kidneys from the mice infected with the wild-type cells showed extensive renal cortical necrosis associated with neutrophilic infiltration. There were also wild-type hyphal cells present in abundance. Hence, tubular necrosis leading to renal failure in the mice may be the cause of death. Although the cph1/cph1 efg1/efg1 mutant cells were not lethal, they were capable of establishing restricted zones of infection and colonization near the renal pelvis instead of simply being cleared by the immune system in mice.
    关键词: Immunology;Pathology;Pharmacology & Pharmacy
    日期: 2006-07
    關聯: International Journal of Immunopathology and Pharmacology. 2006 Jul-Sep;19(3):561-565.
    Link to: http://www.ncbi.nlm.nih.gov/sites/entrez?myncbishare=nhrilib&Db=pubmed&Cmd=DetailsSearch&Term=17026841
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0394-6320&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000241176600012
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33750063508
    显示于类别:[羅秀容] 期刊論文
    [黃秀芬] 期刊論文
    [蘇益仁(2002-2015)] 期刊論文
    [陳炯東] 期刊論文

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