國家衛生研究院 NHRI:Item 3990099045/2052

NHRI > National Institute of Infectious Diseases and Vaccinology > Hsiu-Jung Lo > Periodical Articles > Item 3990099045/2052

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2052

Title:	Non-lethal Candida albicans cph1/cph1 efg1/efg1 transcription factor mutant establishing restricted zone of infection in a mouse model of systemic infection
Authors:	Chen, CG;Yang, YL;Cheng, HH;Su, CL;Huang, SF;Chen, CT;Liu, YT;Su, IJ;Lo, HJ
Contributors:	Division of Clinical Research;Division of Biotechnology and Pharmaceutical Research;Division of Molecular and Genomic Medicine
Abstract:	The cph1/cph1 efg1/efg1andida albicans mutant cells were non-lethal in a mouse model of systemic infection. We investigated in vivo proliferation and invasion of C albicans cells in infected mice to elucidate the interaction between the host and the pathogen. Homogenates of kidneys from the mice infected with the wild-type and the mutant C albicans cells yielded a mean of 2.1 x 10(7)CFU/g and 2.2 x 10(6) CFU/g, respectively. The kidneys from the mice infected with the wild-type cells showed extensive renal cortical necrosis associated with neutrophilic infiltration. There were also wild-type hyphal cells present in abundance. Hence, tubular necrosis leading to renal failure in the mice may be the cause of death. Although the cph1/cph1 efg1/efg1 mutant cells were not lethal, they were capable of establishing restricted zones of infection and colonization near the renal pelvis instead of simply being cleared by the immune system in mice.
Keywords:	Immunology;Pathology;Pharmacology & Pharmacy
Date:	2006-07
Relation:	International Journal of Immunopathology and Pharmacology. 2006 Jul-Sep;19(3):561-565.
Link to:	http://www.ncbi.nlm.nih.gov/sites/entrez?myncbishare=nhrilib&Db=pubmed&Cmd=DetailsSearch&Term=17026841
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0394-6320&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000241176600012
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33750063508
Appears in Collections:	[Hsiu-Jung Lo] Periodical Articles [Shiu-Feng Kathy Huang] Periodical Articles [Ih-Jen Su(2002-2015)] Periodical Articles [Chiung-Tong Chen] Periodical Articles

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