| 2014-09 |
Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents |
Bioorganic and Medicinal Chemistry. 2014 Sep;22(17):4917-4923. |
 |
| 2014-08 |
Two new acidic diterpenoids from the heartwood of Pinus massoniana LAMB |
Helvetica Chimica Acta. 2014 Aug;97(8):1146-1151. |
|
| 2013-11-21 |
治療癌症的醫藥組成物 |
I415852/2013-11-21 |
|
| 2013-09 |
MPT0B098, a novel microtubule inhibitor that destabilizes the hypoxia-inducible factor-1α mrna through decreasing nuclear-cytoplasmic translocation of RNA-binding protein HuR [Erratum: Molecular Cancer Therapeutics. 2013 Jul;12(7):1202-1212.] |
Molecular Cancer Therapeutics. 2013 Sep;12(9):1919. |
|
| 2013-09 |
Furanylazaindoles: Potent anticancer agents in vitro and in vivo |
Journal of Medicinal Chemistry. 2013 Sep;56(20):8008-8018. |
|
| 2013-07-19 |
Surface alpha-enolase promotes extracellular matrix degradation and tumor metastasis and represents a new therapeutic target |
PLoS ONE. 2013 Jul 19;8(7):Article number e69354. |
|
| 2013-07 |
MPT0B098, a novel microtubule inhibitor that destabilizes the hypoxia-inducible factor-1 alpha mRNA through decreasing nuclear-cytoplasmic translocation of RNA-binding protein HuR |
Molecular Cancer Therapeutics. 2013 Jul;12(7):1202-1212. |
|
| 2013-06 |
Aconitamide, a novel alkaloid from the roots of aconitum carmichaeli |
Natural Product Communications. 2013 Jun;8(6):827-828. |
|
| 2013-06 |
Two new lignans from the wood of cunninghamia konishii |
Natural Product Communications. 2013 Jun;8(6):805-806. |
|
| 2013-03-15 |
Analgesic and anti-inflammatory bioactivities of eburicoic acid and dehydroeburicoic acid isolated from antrodia camphorata on the inflammatory mediator expression in mice |
Journal of Agricultural and Food Chemistry. 2013 Mar 15;61(21):5064-5071. |
|
| 2013-03-12 |
A novel synthetic microtubule inhibitor, MPT0B214 exhibits antitumor activity in human tumor cells through mitochondria-dependent intrinsic pathway |
PLoS ONE. 2013 Mar 12;8(3):Article number e58953. |
|
| 2012-12 |
Arginine deprivation as a new treatment strategy for head and neck cancer |
Oral Oncology. 2012 Dec;48(12):1227-1235. |
|
| 2012-12 |
An efficient, mild and scalable synthesis of bioactive compounds containing the angelicin scaffold |
Journal of the Chinese Chemical Society. 2012 Dec;59(12):1548-1554. |
|
| 2012-12 |
Application of Suzuki arylation, Sonogashira ethynylation and Rosenmund-von Braun cyanation in the exploration of substitution effects on the anticancer activity of 2-aroylquinolines |
Organic and Biomolecular Chemistry. 2012 Dec;10(48):9593-9600. |
|
| 2012-11 |
Blockage of Nrf2/AKR1C axis enhanced therapeutic efficacy of oxaliplatin in oxaliplatin resistant gastric cancer cells |
European Journal of Cancer. 2012 Nov;48(Suppl. 6):48. |
|
| 2012-10 |
Adlay (薏苡 yi yi; “soft-shelled job’s tears”, the seeds of Coix lachryma-jobi L. var. ma-yuen Stapf) is a potential cancer chemopreventive agent toward multistage carcinogenesis processes |
Journal of Traditional and Complementary Medicine. 2012 Oct;2(4):267-275. |
|
| 2012-04 |
Targeting cathepsin S induces tumor cell autophagy via the EGFR-Erk signaling pathway |
Cancer Letters. 2012 Apr;317(1):89-98. |
|
| 2012-03 |
4-Ketopinoresinol, a novel naturally occurring ARE activator, induces the Nrf2/HO-1 axis and protects against oxidative stress-induced cell injury via activation of PI3K/AKT signaling |
Free Radical Biology and Medicine. 2012 Mar;52(6):1054-1066. |
|
| 2011-12-22 |
5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2 |
Journal of Medicinal Chemistry. 2011 Dec 22;54(24):8517-8525. |
|
| 2011-12-15 |
Combination of arsenic trioxide and BCNU synergistically triggers redox-mediated autophagic cell death in human solid tumors |
Free Radical Biology and Medicine. 2011 Dec 15;51(12):2195-2209. |
|
| 2011-11-15 |
Coumarin compounds and their use for treating cancer |
US8058427B2/2011-11-15 |
|
| 2011-10 |
Novel terpenoids from calocedrus macrolepis var. formosana |
Chemistry and Biodiversity. 2011 Oct;8(10):1901-1907. |
|
| 2011-09 |
Synthesis and biological evaluation of 1-(4′-Indolyl and 6′-Quinolinyl) indoles as a new class of potent anticancer agents |
European Journal of Medicinal Chemistry. 2011 Sep;46(9):3623-3629. |
|
| 2011-09 |
DNA repair enzyme, O6-methylguanine DNa methyltransferase, modulates therapeutic efficacy of platinum drugs with radiation and its clinical significance |
European Journal of Cancer. 2011 Sep;47:S132. |
|
| 2011-06 |
Antimutagenic constituents of adlay ( Coix lachryma-jobi L. var. ma-yuen Stapf) with potential cancer chemopreventive activity |
Journal of Agricultural and Food Chemistry. 2011 Jun;59(12):6444-6452. |
|
| 2011-06 |
Cytotoxic steroidal saponins from agave sisalana |
Planta Medica. 2011 Jun;77(9):929-933. |
|
| 2011-04-28 |
Scaffold-hopping strategy: Synthesis and biological evaluation of 5,6-Fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents |
Journal of Medicinal Chemistry. 2011 Apr 28;54(8):3076-3080. |
|
| 2011-04 |
Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: application of the copper-mediated Ullmann-type arylation |
Organic and Biomolecular Chemistry. 2011 Apr;9(9):3154-3157. |
|
| 2011-04 |
Activation of Akt/FoxO axis confers resistance to cisplatin in human nasopharyngeal carcinomas |
Cancer Research. 2011 Apr;71:Abstract number 1701. |
|
| 2011-04 |
Activation of NRF2/ABCC1 axis confers resistance to topoisomerase II poisons in human oral malignancies |
Cancer Research. 2011 Apr;71:Abstract number 1528. |
|
| 2011-04 |
MPT0B098, a novel microtubule inhibitor, displays potent anti-angiogenic activity via destabilizing hypoxia-inducible factor-1alpha mRNA |
Cancer Research. 2011 Apr;71(Suppl. 8):Meeting Abstract 4461. |
|
| 2011-04 |
Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway |
Cancer Research. 2011 Apr;71(Suppl. 8):Meeting Abstract 2864. |
|
| 2011-03-07 |
Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents |
Molecules. 2011 Mar 7;16(3):2274-2284. |
|
| 2011-03-07 |
2-Amino-3,4,5-Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors |
ChemMedChem. 2011 Mar 7;6(3):450-456. |
|
| 2011-01-26 |
Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana |
Tetrahedron Letters. 2011 Jan 26;52(4):515-517. |
|
| 2010-10 |
Combined modalities of resistance in a cisplatin-driven human betel-associated oral squamous cell carcinoma |
Annals of Oncology. 2010 Oct;21(Suppl. 8):52. |
|
| 2010-08 |
Synthesis and biological evaluation of 7-arylindoline-1-benzenesulfonamides as a novel class of potent anticancer agents |
MedChemComm. 2010 Aug;1(2):152-155. |
|
| 2010-06-18 |
Cytotoxic C35 terpenoid cryptotrione from the bark of cryptomeria japonica |
Organic Letters. 2010 Jun;12(12):2786-2789. |
|
| 2010-06 |
Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis |
Journal of Medicinal Chemistry. 2010 Jun;53(11):4545-4549. |
|
| 2010-05 |
Chamaecypanone C, a novel skeleton microtubule inhibitor, with anticancer activity by trigger caspase 8-Fas/FasL dependent apoptotic pathway in human cancer cells |
Biochemical Pharmacology. 2010 May;79(9):1261-1271. |
|
| 2010-04 |
Arecoline arrests cells at prometaphase by deregulating mitotic spindle assembly and spindle assembly checkpoint: Implication for carcinogenesis |
Oral Oncology. 2010 Apr;46(4):255-262. |
|
| 2010-03-11 |
5-Amino-2-Aroylquinolines as Highly Potent Tubulin Polymerization Inhibitors |
Journal of Medicinal Chemistry. 2010 Mar 11;53(5):2309-2313. |
|
| 2009-11-01 |
Effects of drying and extrusion on colour, chemical composition, antioxidant activities and mitogenic response of spleen lymphocytes of sweet potatoes |
Food Chemistry. 2009 Nov 1;117(1):114-121. |
|
| 2009-09 |
Synergistic augmentation of arsenic trioxide-induced cytotoxicity by BCNU through reactive oxygen species-related autophagic pathway in human solid tumors |
EJC Supplements. 2009 Sep;7(3):16. |
|
| 2009-08-13 |
Synthesis and evaluation of 3-aroylindoles as anticancer agents: Metabolite approach |
Journal of Medicinal Chemistry. 2009 Aug 13;52(15):4941-4945. |
|
| 2009-07-23 |
Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity |
Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4221-4233. |
|
| 2009-07-03 |
Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers |
Molecular Cancer. 2009 Jul 3;8:Article number 43. |
|
| 2009-05 |
HQO-0601, an amide-containg 3, 4-dihydroquinolinone derivative, against human hematologic malignancies through inhibition of mammalian target of repamycin signaling pathway |
Cancer Research. 2009 May;69:Abstract number LB-51. |
|
| 2009-04-17 |
Synthesis and structure-activity relationships of 1-benzyl-4,5,6-trimethoxyindoles as a novel class of potent antimitotic agents |
ChemMedChem. 2009 Apr 17;4(4):588-593. |
|
| 2008-12-25 |
Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents |
Journal of Medicinal Chemistry. 2008 Dec 25;51(24):8163-8167. |
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