國家衛生研究院 NHRI:Item 3990099045/1964
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1964


    Title: Variety of TEM-, SHV-, and CTX-M-type beta-lactamases present in recent clinical isolates of Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae from Taiwan
    Authors: Ma, L;Chang, FY;Fung, CP;Chen, TL;Lin, JC;Lu, PL;Huang, LY;Chang, JC;Siu, LK
    Contributors: Division of Clinical Research
    Abstract: A total of 171 hospitals' isolates of E. coli, K. pneumoniae, and E. cloacae with a minimum inhibitory concentration (MIC) of >= 2 mu g/ml for ceftazidime or cefotaxime were evaluated for the production of beta-lactamases. PCR amplification with specific primers for the bla(SHV), bla(TEM), and bla(CTX) genes revealed that a total of 53, 81, and 43 of these genes were amplified, respectively. Sequencing results confirmed that TEM-1, CTX-M-3 and -14, SHV-1, -5, -11, -12, and -33, OXY-1a, and LEN-1 were presented among these isolates. No specific large cluster of isolates carried the same beta-lactamases, indicating the wide diversity of the collected strains. Plasmid spread between E. coli and K. neumoniae was identified in few isolates. Combinations of TEM, SHV, and CTX beta-lactamase genes, including extended-spectrum beta-lactamase genes, were observed in all three species.
    Keywords: Infectious Diseases;Microbiology;Pharmacology & Pharmacy
    Date: 2005-SPR
    Relation: Microbial Drug Resistance. 2005 Spr;11(1):31-39.
    Link to: http://dx.doi.org/10.1089/mdr.2005.11.31
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1076-6294&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000227602500006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=14944370004
    Appears in Collections:[Leung-Kei Siu] Periodical Articles

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