國家衛生研究院 NHRI:Item 3990099045/1951
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    题名: High carriage rate of high-level penicillin-resistant Streptococcus pneumoniae in a Taiwan kindergarten associated with a case of pneumococcal meningitis
    作者: Lauderdale, TL;Lee, Y;Cheng, MF;Huang, IF;Lin, YC;Hseih, KS;Huang, IW;Chiou, CC
    贡献者: Division of Clinical Research
    摘要: Background: The Taiwan(19F)- 14 Streptococcus pneumoniae clone and its variants are being found with increasing frequency in the Asia-Pacific region. A 5-year old child with S. pneumoniae meningitis caused by a high-level penicillin resistant strain ( MIC = 4 mu g/ml) was admitted to a hospital in southern Taiwan. We carried out a study to determine the potential source of this strain. Methods: Nasopharyngeal cultures were obtained from all children attending the same kindergarten as the index case. To determine their relatedness all isolates were compared by serotype, antimicrobial susceptibility profile and pulsed field gel electrophoresis (PFGE). Results: A high proportion of the children including the index case (32/78, 41.0%) carried S. pneumoniae in their nasopharynx (NP). The most common serotype was 19F (13/32, 40.6%). The PFGE types of the 19F serotype isolates obtained from the patient's blood, CSF and NP were identical and were related to 11 other serotype 19F NP isolates including 10 that were indistinguishable from the Taiwan19F- 14 clone. All 14 isolates had similar high-level penicillin and multi-drug resistance. The serotypes of the other 19 NP isolates included 6A ( 2), 6B ( 10), 23F ( 5), 9V ( 1) and 3 ( 1). The overall rate of penicillin resistance in these S. pneumoniae from these children was 87.5% (28/32), with an MIC50 of 2 and MIC90 of 4 ug/ ml. In addition, multi-drug resistant-isolates ( isolates resistant to 3 different classes of antimicrobials) accounted for 87.5% (28/32) of all isolates. Conclusion: The high carriage rate of high-level penicillin-and multi-drug-resistant S. pneumoniae in a kindergarten associated with a case of pneumococcal meningitis emphasizes the need for restraint in antibiotic use and consideration of childhood immunization with conjugate pneumococcal vaccine to prevent the further spread of resistant S. pneumoniae in Taiwan.
    关键词: Infectious Diseases
    日期: 2005-11-01
    關聯: BMC Infectious Diseases. 2005 Nov;5:Article number 96.
    Link to: http://dx.doi.org/10.1186/1471-2334-5-96
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1471-2334&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000233550300001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=27744447180
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