國家衛生研究院 NHRI:Item 3990099045/1920
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    题名: Induction of the early growth response 1 gene by Epstein-Barr virus lytic transactivator Zta
    作者: Chang, Y;Lee, HH;Chen, YT;Lu, J;Wu, SY;Chen, CW;Takada, K;Tsai, CH
    贡献者: Division of Clinical Research
    摘要: Early growth response 1 (Egr-1) is a cellular transcription factor involved in diverse biologic functions. Egr-1 has been associated with Epstein-Barr virus (EBV) infection, but it is still unknown whether any EBV protein regulates Egr-1 expression. In this study, we first showed that EBV reactivation is involved in upregulation of Egr-1 and that Egr-1 can be induced by Zta, an EBV lytic transactivator. Zta not only binds to the Egr-1 promoter but also activates the ERK signaling pathway to trigger binding of Elk-1 to the Egr-1 promoter. In addition, knockdown of Egr-1 significantly reduces the spontaneous expression of Zta and Rta in EBV-infected 293 cells, suggesting that a positive-feedback network involving Egr-1 is required for EBV reactivation. This study also implies that Zta has the potential to affect expression of certain genes through Egr-1.
    关键词: Virology
    日期: 2006-08
    關聯: Journal of Virology. 2006 Aug;80(15):7748-7755.
    Link to: http://dx.doi.org/10.1128/JVI.02608-05
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-538X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000239189100046
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33746215094
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