國家衛生研究院 NHRI:Item 3990099045/1904

NHRI > National Institute of Infectious Diseases and Vaccinology > Monto Ho(1997-2002) > Periodical Articles > Item 3990099045/1904

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1904

Title:	Bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a pediatric oncology ward: Clinical features and identification of different plasmids carrying both SHV-5 and TEM-1 genes
Authors:	Siu, LK;Lu, PL;Hsueh, PR;Lin, FM;Chang, SC;Luh, KT;Ho, M;Lee, CY
Contributors:	Division of Clinical Research
Abstract:	Thirteen patients who had 16 episodes of bacteremia were observed between 1993 and 1997 in a pediatric oncology ward with a high background isolation rate of cefotaxime- or aztreonam-resistant gram-negative bacteria, Four blood isolates were Escherichia coli and 12 were Klebsiella pneumonine, and these isolates harbored extended-spectrum beta-lactamases (ESBLs), All episodes of bacteremia were nosocomial, all except one of the episodes occurred in neutropenic patients, and all patients were treated with piperacillin or ceftazidime with amikacin and cefazolin prior to the onset of bacteremia, Nine of 13 patients were receiving extended-spectrum beta-lactam treatment when the bacteremias caused by ESBL producers occurred. Molecular studies revealed that four K. pneumoniae SHV-2-producing isolates from 1994 were of the same clone. Other ESBL producers, including six that carried both TEM-1 and SHV-5, five that carried SHV-5 and one that carried SHV-2 alone, were unrelated. In conclusion, SHV-5 was present in 11 of the 16 isolates and coexisted with TEM-1 in 6 isolates. Acquisition of resistance genes probably occurred under antibiotic selection pressure. This study highlights the importance of routine checks for and detection of ESBL producers. Effective therapy against ESBL producers should he considered early for children who have malignancies and neutropenia and who are septic, despite treatment with a regimen that includes an extended-spectrum beta-lactam, in a clinical setting of an increased incidence of ESBL-producing bacteria.
Keywords:	Microbiology
Date:	1999-12
Relation:	Journal of Clinical Microbiology. 1999 Dec;37(12):4020-4027.
Link to:	http://jcm.asm.org/cgi/content/abstract/37/12/4020
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0095-1137&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000083877400039
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0032701986
Appears in Collections:	[Monto Ho(1997-2002)] Periodical Articles [Leung-Kei Siu] Periodical Articles

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