| 2024-09 |
Enhanced non-viral gene delivery via calcium phosphate/DNA co-precipitates with low-voltage pulse electroporation in NK-92 cells for immunocellular therapy |
APL Bioengineering. 2024 Sep;8:Article number 036107. |
 |
| 2023-08 |
Mechanical transmission of dengue virus by Aedes aegypti may influence disease transmission dynamics during outbreaks |
eBioMedicine. 2023 Aug;Article number 104723. |
|
| 2022-06 |
The cargo adapter protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection |
Journal of Biological Chemistry. 2022 Jun;298(6):Article number 101956. |
|
| 2021-03-30 |
Aggressive organ penetration and high vector transmissibility of epidemic dengue virus-2 Cosmopolitan genotype in a transmission mouse model |
PLoS Pathogens. 2021 Mar 30;17(3):Article number e1009480. |
|
| 2019-12 |
A novel flavivirus entry inhibitor, BP34610, discovered through high-throughput screening with dengue reporter viruses |
Antiviral Research. 2019 Dec;172:Article number 104636. |
|
| 2019-08-27 |
A dengue virus type 2 (DENV-2) NS4B-interacting host factor, SERP1, reduces DENV-2 production by suppressing viral RNA replication |
Viruses. 2019 Aug 27;11(9):Article number 787. |
|
| 2019-07 |
Nucleoside analogs with selective antiviral activity against dengue fever and Japanese encephalitis viruses |
Antimicrobial Agents and Chemotherapy. 2019 Jul;63(7):e00397-19. |
|
| 2019-04-01 |
A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus |
European Journal of Medicinal Chemistry. 2019 Apr 1;167:245-268. |
|
| 2019-03 |
Mutagenesis of the dengue virus NS4A protein reveals a novel cytosolic N-terminal domain responsible for virus-induced cytopathic effects and intramolecular interactions within the N-terminus of NS4A |
Journal of General Virology. 2019 Mar;100(3):457-470. |
|
| 2018-09 |
Development of robust genotype 1a hepatitis C replicons harboring adaptive mutations for facilitating the antiviral drug discovery and study of virus replication |
Journal of Virological Methods. 2018 Sep;259:10-17. |
|
| 2018-07-26 |
The conserved stem-loop II structure at the 3' untranslated region of Japanese encephalitis virus genome is required for the formation of subgenomic flaviviral RNA |
PLoS ONE. 2018 Jul 26;13(7):Article number e0201250. |
|
| 2017-06 |
Mutagenesis of dengue virus protein NS2A revealed a novel domain responsible for virus-induced cytopathic effect and interactions between NS2A and NS2B transmembrane segments |
Journal of Virology. 2017 Jun;91(12):Article number e01836-16. |
|
| 2017-01 |
A potent, selective, and orally bioavailable HCV NS5A inhibitor for treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazo l-2-yl)pyrrolidine-2-carboxamide |
Journal of Medicinal Chemistry. 2017 Jan;60(1):228-247. |
|
| 2015-10 |
Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening |
Journal of Medicinal Chemistry. 2015 Oct;58 (19):7807-7819. |
|
| 2015-06-01 |
治療C型肝炎病毒感染之醫藥組成物 |
I486160/2015-06-01 |
|
| 2015-04 |
Scanning mutagenesis studies reveal a potential intramolecular interaction within the C-Terminal half of Dengue Virus NS2A involved in viral RNA replication and virus assembly and secretion |
Journal of Virology. 2015 Apr;89(8):4281-4295. |
|
| 2014-07 |
A novel approach to propagate flavivirus infectious cDNA clones in bacteria by introducing tandem repeat sequences upstream of virus genome |
Journal of General Virology. 2014 Jul;95(Pt 7):1493-1503. |
|
| 2014-06-26 |
Baicalin, a metabolite of baicalein with antiviral activity against dengue virus |
Scientific Reports. 2014 Jun 26;4:Article number 5452. |
|
| 2014-01 |
A novel dengue virus inhibitor, BP13944, discovered by high-throughput screening with dengue virus replicon cells selects for resistance in the viral NS2B/NS3 protease |
Antimicrobial Agents and Chemotherapy. 2014 Jan;58(1):110-119. |
|
| 2013-05 |
Characterization of an efficient dengue virus replicon for development of assays of discovery of small molecules against dengue virus |
Antiviral Research. 2013 May;98(2):228-241. |
|
| 2013-02 |
Resistance studies of a di-thiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems |
Antimicrobial Agents and Chemotherapy. 2013 Feb; 57(2):723-733. |
|
| 2012-04-11 |
咪唑啉酮及咪唑啉硫酮衍生物 |
I361808/2012-04-11 |
|
| 2012-01 |
Resistance analysis and characterization of a thiazole analogue, BP008, as a potent hepatitis C virus NS5A inhibitor |
Antimicrobial Agents and Chemotherapy. 2012 Jan;56(1):44-53. |
|
| 2011-05-10 |
Imidazolidinone and imidazolidinethione derivatives |
US7939523B2/2011-05-10 |
|
| 2011-04 |
Isatin-beta-thiosemicarbazones as potent herpes simplex virus inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2011 Apr;21(7):1948-1952. |
|
| 2011-03 |
Successful propagation of flavivirus infectious cDNAs by a novel method to reduce the cryptic bacterial promoter activity of virus genomes |
Journal of Virology. 2011 Mar;85(6):2927-2941. |
|
| 2011-01 |
Novel dengue virus-specific NS2B/NS3 protease inhibitor, BP2109, discovered by a high-throughput screening assay |
Antimicrobial Agents and Chemotherapy. 2011 Jan;55(1):229-238. |
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| 2010-09-01 |
Synthesis, activity, and pharmacokinetic properties of a series of conformationally-restricted thiourea analogs as novel hepatitis C virus inhibitors |
Bioorganic and Medicinal Chemistry. 2010 Sep ;18(17):6414-6421. |
|
| 2009-11-01 |
Design and efficient synthesis of novel arylthiourea derivatives as potent hepatitis C virus inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2009 Nov 1;19(21):6063-6068. |
|
| 2009-08-01 |
Design and synthesis of indole, 2,3-dihydro-indole, and 3,4-dihydro-2H-quinoline-1-carbothioic acid amide derivatives as novel HCV inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2009 Aug 1;19(15):4134-4138. |
|
| 2009-02 |
A novel dengue vaccine candidate that induces cross-neutralizing antibodies and memory immunity |
Microbes and Infection. 2009 Feb;11(2):288-295. |
|
| 2006-05-04 |
Structure-based drug design of a novel family of PPAR gamma partial agonists: Virtual screening, X-ray crystallography, and in vitro/in vivo biological activities |
Journal of Medicinal Chemistry. 2006 May;49(9):2703-2712. |
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