國家衛生研究院 NHRI:Item 3990099045/1877
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    题名: Directly measured insulin resistance and the assessment of clustered cardiovascular risks in hypertension
    作者: Lin, MW;Hwu, CM;Huang, YH;Sheu, WHH;Shih, KC;Chiang, FT;Olshen, R;Chen, YDI;Curb, JD;Rodriguez, B;Ho, LT
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: Background: The purpose of the study was to use factor analysis to investigate the contribution of a directly measured insulin sensitivity index, steady-state plasma glucose (SSPG) from insulin suppression test (IST), to a clustering of cardiovascular risk factors in hypertensive subjects. Methods: A total of 204 nondiabetic hypertensive patients who received IST for SSPG were included for current analysis. Factor analysis was performed to explore the contribution of SSPG as additional information to a clustering of risk factors in these subjects. Results: In factor analysis, SSPG aggregated with metabolic variables in an obesity-hyperinsulinemia domain that included two factors: one with positive loadings for SSPG, 2-h glucose, and Log 2-h insulin; and the other with positive loadings for body mass index, waist circumference, and fasting glucose. Fasting insulin linked the two factors together and explained 38.3% of the total variance. Systolic and diastolic blood pressures were loaded on a blood pressure domain separately. The third domain consisted of two factors: one with positive loadings for Log triglycerides and negative loading for high-density lipoprotein cholesterol; and the other with positive loadings for Log triglycerides and non-high-density lipoprotein cholesterol. The model loaded without SSPG explained a proportion of the total variance (78.5%) similar to that achieved with the model loaded with SSPG (77.1%). Conclusions: Directly measured insulin sensitivity index SSPG clustered with 2-h glucose and Log 2-h insulin in factor analysis in a cohort consisting entirely of hypertensive subjects. However, the contribution of SSPG as additional information to explain the total variance seems to be insignificant.
    关键词: Peripheral Vascular Disease
    日期: 2006-11
    關聯: American Journal of Hypertension. 2006 Nov;19(11):1118-1124.
    Link to: http://dx.doi.org/10.1016/j.amjhyper.2006.04.003
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0895-7061&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000242142400006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33750332992
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