國家衛生研究院 NHRI:Item 3990099045/1876
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    题名: Human papillomaviral load changes in low-grade squamous intraepithelial lesions of the uterine cervix
    作者: Ho, CM;Cheng, WF;Chu, TY;Chen, CA;Chuang, MH;Chang, SF;Hsieh, CY
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: To better predict risk of progression of low-grade squamous intraepithelial lesions (LSILs) of the uterine cervix in women with human papillomavirus (HPV) infections, 294 baseline cervical specimens from women with LSILs were evaluated. Specimens were tested for HPV DNA using hybrid capture 2 (HC2) and PCR-reverse line blotting. 65 LSILs with HPV DNA types 16, 18, 52, or 58 were examined for physical status, E2/E6 ratio and viral load at two time points, along with patient age. Women with LSILs whose viral loads increased between baseline and 6 month follow-up had a 45% risk of developing HSIL (OR = 7.6, 95% CI = 1.9-29.4, P < 0.01), as evaluated by real-time PCR and a 44% risk (OR = 6.1, 95% CI = 1.6-22.7, P < 0.01), as evaluated by HC2. The two viral load measures correlated well (Person's coefficient, r = 0.687, P < 0.001). Such evaluations of viral load changes ( increased or not increased) through repeat HPV DNA testing could predict progression of disease in LSIL cases of HPV types 16, 18, 52, and 58, which correlates to clinical implications.
    关键词: Oncology
    日期: 2006-11-20
    關聯: British Journal of Cancer. 2006 Nov;95(10):1384-1389.
    Link to: http://dx.doi.org/10.1038/sj.bjc.6603430
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0007-0920&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000242046700013
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33751028953
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