國家衛生研究院 NHRI:Item 3990099045/1827
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1827


    Title: Physical inactivity is an important lifestyle determinant of insulin resistance in hypertensive patients
    Authors: Hwu, CM;Hsiao, CF;Kuo, SW;Wu, KD;Ting, CT;Quertermous, T;Rodriguez, B;Chen, I;Grove, J;Chen, PY;Ho, LT
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: The purpose of the study is to assess the relative impact of lifestyle factors including physical inactivity, cigarette smoking, and alcohol intake on insulin resistance in hypertensive patients. In total, 872 hypertensive patients, of Chinese and Japanese origin, from the Stanford Asia and Pacific Program for Hypertension and Insulin Resistance were included for the current analysis. Homeostasis model assessment for insulin resistance (HOMA-IR) and the insulin sensitivity index ISI0,120 were chosen as surrogate measures of insulin resistance. Standardized interview-administered questionnaires were used to obtain information on demographic and lifestyle characteristics. The sedentary hypertensive patients were more insulin resistant than the non-sedentary hypertensive. There were significant differences in Loa (HOMA-IR) (0.06-unit increases, p < 0.01) and Log (ISI0.120) (0.05-unit decreases, p < 0.01) between sedentary and non-sedentary hypertensive patients after controlling demographic variables. There were no differences in insulin sensitivity in subjects with different smoking status. Neither smoking nor alcohol intake was persistently associated with insulin resistance in the analysis. Our results suggest that physical inactivity is an important lifestyle determinant of insulin resistance in hypertensive patients. The influences of smoking and alcohol intake on insulin resistance are less significant than physical inactivity in hypertensive subjects.
    Keywords: Peripheral Vascular Disease
    Date: 2004
    Relation: Blood Pressure. 2004;13(6):355-361.
    Link to: http://dx.doi.org/10.1080/08037050410004828
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0803-7051&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000225937200007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=19944398418
    Appears in Collections:[Chin-Fu Hsiao] Periodical Articles

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