國家衛生研究院 NHRI:Item 3990099045/1818
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1818


    Title: Sagittal abdominal diameter is associated with insulin sensitivity in Chinese hypertensive patients and their siblings
    Authors: Hwu, CM;Hsiao, CF;Sheu, WHH;Pei, D;Tai, TY;Quertermous, T;Rodriguez, B;Pratt, R;Chen, YDI;Ho, LT
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: The purpose of the study is to observe the relation between anthropometric measurements, focusing on sagittal abdominal diameter (SAD), and insulin sensitivity indices in Chinese hypertensive patients and their siblings. In total, 907 participants, 537 hypertensive and 370 non hypertensive, from 311 Taiwanese families were drawn from the Stanford Asia and Pacific Program for Hypertension and Insulin Resistance for the study. The participants received anthropometric measurements and 75-g oral glucose tolerance tests after an overnight fast. Fasting insulin, homeostasis model assessment for insulin resistance (HOMA-IR), and the insulin sensitivity index ISI0,120 were chosen as surrogate measures of insulin sensitivity. In addition to Pearson and partial correlations, we used generalized estimating equations (GEEs) to examine the association between anthropometric measurements and insulin sensitivity indices. A small deviance in the GEEs indicates the goodness of model fit, irrespective of the independence among variables. The hypertensive patients were older in age, wider in waist circumference (WC), larger in body mass index (BMI) and SAD, and more insulin resistant than the nonhypertensive counterparts. The logarithmic transformation of fasting insulin, HOMA-IR, and ISI0,120. significantly correlated with SAD, WC, and BMI before and after adjustments for age and sex. The deviances of SAD in the GEEs were similar to those of WC in all subjects, while BMI had smaller deviances than SAD and WC in the hypertensive patients. Our results suggest that the performance of SAD in predicting insulin sensitivity is comparable with WC in Chinese hypertensive patients and their siblings. BMI, however, seems to have better association with insulin sensitivity than SAD and WC in the patients with hypertension.
    Keywords: Peripheral Vascular Disease
    Date: 2003-03
    Relation: Journal of Human Hypertension. 2003 Mar;17(3):193-198.
    Link to: http://dx.doi.org/10.1038/sj.jhh.1001532
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0950-9240&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000182115100007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037349408
    Appears in Collections:[Chin-Fu Hsiao] Periodical Articles

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