國家衛生研究院 NHRI:Item 3990099045/1811
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1811


    Title: Prevalence of Toxoplasma gondii infection and incidence of toxoplasma encephalitis in non-haemophiliac HIV-1-infected adults in Taiwan
    Authors: Hung, CC;Chen, MY;Hsieh, SM;Hsiao, CF;Sheng, WH;Chang, SC
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: We assessed the seroprevalence of Toxoplasma gondii infection and incidence of toxoplasma encephalitis (TE) in 844 non-haemophiliac HIV-infected patients in Taiwan between June 1994 and April 2003. Approximately 70% (69.3%) of them had a baseline CD4 + lymphocyte count of 200 x 10(6)/L or less, and more than 70% (73.9%) having initiated highly active antiretroviral therapy. The seroprevalence of T. gondii infection was 10.2%, which did not differ with sex, age, route of transmission, birth inside or outside of Taiwan, or CD4 + lymphocyte stratifications. After a median observation duration of 603 days (range, 1-3264 days), 10 (1.2% patients developed 11 episodes of TE after a median interval of 30 days (range, 1-941 days) between enrolment and diagnosis of TE, with an incidence of 0.59 per 100 person-years (PY) (95% confidence interval, 0.56-0.63 per 100 PY). We concluded that the incidence of TE of HIV-infected patients in Taiwan was lower than that reported in western countries because of a lower seroprevalence of T. gondii infection and use of antimicrobial prophylaxis and antiretroviral therapy, although most of the patients were at the late stage of HIV infection.
    Keywords: Immunology;Infectious Diseases
    Date: 2005-04
    Relation: International Journal of STD and AIDS. 2005 Apr;16(4):302-306.
    Link to: http://dx.doi.org/10.1258/0956462053654230
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0956-4624&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000229073900009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=18744416009
    Appears in Collections:[Chin-Fu Hsiao] Periodical Articles

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