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http://ir.nhri.org.tw/handle/3990099045/1806
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| Title: | Surrogate estimates of insulin sensitivity in subjects with hypertension |
| Authors: | Hwu, CM;Hsiao, CF;Grove, J;Hung, YJ;Chuang, LM;T Chen, Y;D Curb, J;Chen, YDI;Rodriguez, B;Ho, LT |
| Contributors: | Division of Biostatistics and Bioinformatics |
| Abstract: | The purpose of the study is to compare surrogate estimates of insulin sensitivity with a directly measured insulin sensitivity index, steady-state plasma glucose (SSPG) from insulin suppression test (IST), in subjects with hypertension. Two hundred and twenty-eight hypertensive patients who received IST for SSPG were included for analysis. Estimates from fasting measurements alone, homeostasis model assessment for insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI)), and indices from fasting and/or 2 h samples (ISI0,120 and ISITX) were calculated. In addition to Pearson and partial correlations, variance-component models were used to test the relationship between surrogate estimates of insulin sensitivity and SSPG. A large proportion of variance owing to covariates in the variance-component models indicated the goodness of model fit, irrespective of the independence among variables. SSPG was positively correlated with logarithmic transformation ( Log) (HOMA-IR) and negatively correlated with QUICKI, Log (ISI0,120) and ISITX ( all P<0.0001). Log ( ISI0,120) seemed to have a better correlation with SSPG (r = -0.72) than other measures in partial correlation. The proportion of variance owing to all covariates of Log (ISI0,120) and ISITX were larger than those of Log (HOMA-IR) and QUICKI in the variance-component models. After adjustments for demographic and obesity covariates, the proportion of variance explained by Log ( ISI0,120) were largest among the surrogate measures in the variance-component models. Our results showed that ISI0,120 and ISITX correlated better with SSPG than those used fasting measures alone (HOMA-IR and QUICKI). Log (ISI0,120) currently showing the strongest association with SSPG than other estimates is adaptable for use in large studies of hypertension. |
| Keywords: | Peripheral Vascular Disease |
| Date: | 2007-03 |
| Relation: | Journal of Human Hypertension. 2007 Mar;21(3):246-252. |
| Link to: | http://dx.doi.org/10.1038/sj.jhh.1002137 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0950-9240&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000244275700007 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33847062500 |
| Appears in Collections: | [蕭金福] 期刊論文
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| 000244275700007.pdf | | 112Kb | Adobe PDF | 586 | View/Open |
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