國家衛生研究院 NHRI:Item 3990099045/1802
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1802


    Title: Improved survival of persons with human immunodeficiency virus type 1 infection in the era of highly active antiretroviral therapy in Taiwan
    Authors: Hung, CC;Hsiao, CF;Chen, MY;Hsieh, SM;Chang, SY;Sheng, WH;Sun, HY;Chang, SC
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: We assessed the survival of 1,044 HIV-infected persons enrolled in three periods: period 1, 1994 to 1997 (before the introduction of highly active antiretroviral therapy [HAART]); period 2, 1997 to 2000 (early-HAART); and period 3, 2000 to 2004 (late-HAART). As of 30 June 2005, 259 (24.8%) persons had died after a median observation duration of 985 days (range, 2-4,025 days). The mortality rate declined from 33.75 per 100 person-years in the pre-HAART era to 6.51 per 100 person-years in the late-HAART era (P < 0.0001). The adjusted hazard ratios for death in persons with a baseline CD4 count of < 200 cells/mu l in periods 2 and 3 were 0.605 (P = 0.007) and 0.371 (P < 0.0001), respectively, when compared with persons enrolled in period 1; the adjusted hazard ratio for death was 0.611 for persons enrolled in period 3 when compared to period 2 (P = 0.01). Our study suggested that the survival of persons in the late stage of HIV infection in Taiwan continued to improve in the late HAART era.
    Keywords: Infectious Diseases
    Date: 2006-08
    Relation: Japanese Journal of Infectious Diseases. 2006 Aug;59(4):222-228.
    Link to: http://www.nih.go.jp/JJID/59/222.html
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1344-6304&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000240271000003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33748120952
    Appears in Collections:[Chin-Fu Hsiao] Periodical Articles

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