國家衛生研究院 NHRI:Item 3990099045/1780
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    題名: Simultaneous non-inferiority test of sensitivity and specificity for two diagnostic procedures in the presence of a gold standard
    作者: Chen, JJ;Hsueh, HM;Liu, JP
    貢獻者: Division of Biostatistics and Bioinformatics
    摘要: Sensitivity and specificity have traditionally been used to assess the performance of a diagnostic procedure. Diagnostic procedures with both high sensitivity and high specificity are desirable, but these procedures are frequently too expensive, hazardous, and/or difficult to operate. A less sophisticated procedure may be preferred, if the loss of the sensitivity or specificity is determined to be clinically acceptable. This paper addresses the problem of simultaneous testing of sensitivity and specificity for an alternative test procedure with a reference test procedure when a gold standard is present. The hypothesis is formulated as a compound hypothesis of two non-inferiority (one-sided equivalence) tests. We present an asymptotic test statistic based on the restricted maximum likelihood estimate in the framework of comparing two correlated proportions under the prospective and retrospective sampling designs. The sample size and power of an asymptotic test statistic are derived. The actual type I error and power are calculated by enumerating the exact probabilities in the rejection region. For applications that require high sensitivity as well as high specificity, a large number of positive subjects and a large number of negative subjects are needed. We also propose a weighted sum statistic as an alternative test by comparing a combined measure of sensitivity and specificity of the two procedures. The sample size determination is independent of the sampling plan for the two tests.
    關鍵詞: Mathematical & Computational Biology;Statistics & Probability
    日期: 2003
    關聯: Biometrical Journal. 2003;45(1):47-60.
    Link to: http://dx.doi.org/10.1002/bimj.200290015
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0323-3847&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000180726600004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037283022
    顯示於類別:[劉仁沛(1998-2002)] 期刊論文

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