國家衛生研究院 NHRI:Item 3990099045/1748
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1748


    Title: Genome-wide linkage analysis of lipids in nondiabetic chinese and Japanese from the SAPPHIRe family study
    Authors: Hsiao, CF;Chiu, YF;Chiang, FT;Ho, LT;Lee, WJ;Hung, YJ;Chen, YDI;Donlon, TA;Jorgenson, E;Curb, D;Risch, N;Hsiung, CA
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: Background: Lipid levels are recognized as major risk factors for coronary heart disease (CHD). Discovery of major loci underlying quantitative lipid traits could help to elucidate the genetics of CHD. Methods: We performed a genome-wide search for quantitative trait loci linked to lipid phenotypes in 1538 Chinese subjects (509 families) and 625 Japanese subjects (204 families) not taking lipid-lowering medications from the Stanford-Asian Pacific Program in Hypertension and Insulin Resistance (SAPPHIRe) study. The multipoint variance-components method was used to test for linkage between marker loci and each trait by maximum likelihood methods adjusted for effects of age, age, gender, body mass index (BMI), smoking, alcohol drinking, physical activity, and field center. Results: The highest logarithm of odds (LOD) score detected was 3.22 for logarithmically transformed HDL-cholesterol on chromosome 12 at 113 cM in Chinese subjects. This score overlaps the positive findings for HDL reported in Mexican Americans (chromosome 12 at 96 cM). Although no strong evidence for linkage was found in Japanese subjects, some modest peaks (LOD score >= 1.5) were found in several regions that have been reported in other published genome scans. For example, the Japanese SAPPHIRe peak for HDL (chromosome I at 167 cM; LOD = 1.54) was very close to the quantitative trait loci (QTL) for HDL reported in the scan of white American HyperGEN (chromosome 1 at 159.9 cM). Conclusions: Genome-wide scan for genes influencing lipid phenotypes was conducted and we found significant linkage of HDL to a locus on chromosome 12 in Chinese subjects and no linkage signal exceeding 1.68 was found in the Japanese subjects.
    Keywords: Peripheral Vascular Disease
    Date: 2006-12
    Relation: American Journal of Hypertension. 2006 Dec;19(12):1270-1277.
    Link to: http://dx.doi.org/10.1016/j.amjhyper.2006.05.004
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0895-7061&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000243237600013
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33845208242
    Appears in Collections:[Chao A. Hsiung] Periodical Articles
    [Yen-Feng Chiu] Periodical Articles
    [Chin-Fu Hsiao] Periodical Articles

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