國家衛生研究院 NHRI:Item 3990099045/1735
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1735


    Title: Single nucleotide polymorphisms in protein tyrosine phosphatase 1 beta (PTPN1) are associated with essential hypertension and obesity
    Other Titles: Single nucleotide polymorphisms in protein tyrosine phosphatase 1ß (PTPN1) are associated with essential hypertension and obesity
    Authors: Olivier, M;Hsiung, CA;Chuang, LM;Ho, LT;Ting, CT;Bustos, VI;Lee, TM;de Witte, A;Chen, YDI;Olshen, R;Rodriguez, B;Wen, CC;Cox, DR
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: Protein tyrosine phosphatase 1beta (PTP-1beta) is involved in the regulation of several important physiological pathways. It regulates both insulin and leptin signaling, and interacts with the epidermal- and platelet-derived growth factor receptors. The gene is located on human chromosome 20q13, and several rare single nucleotide polymorphisms (SNPs) have been shown to be associated with insulin resistance and diabetes in different populations. As part of our ongoing investigations into the genetic basis of hypertension, we examined common sequence variants in the gene for association with hypertension, obesity and altered lipid profile in two populations of Japanese and Chinese descent. We re-sequenced all exons, selected intronic sequences and the promoter region in 24 individuals from our cohort. Fourteen SNPs were discovered, and six of these spanning 78 kb were genotyped in 1553 individuals from 672 families. All six SNPs were in linkage disequilibrium, and we found strong association of common risk haplotypes with hypertension in Chinese and Japanese (P<0.0001). In addition, individual SNPs showed association to total plasma cholesterol, LDL-cholesterol and VLDL-cholesterol levels, as well as obesity measures (body mass index). This analysis supports that PTP-1β affects plasma lipid levels, and may lead to obesity and hypertension in Japanese and Chinese. Given similar associations found in other populations to insulin resistance and diabetes, this gene may play a crucial role in the development of the characteristic metabolic changes seen in patients with the metabolic syndrome.
    Keywords: Biochemistry & Molecular Biology;Genetics & Heredity
    Date: 2004-09-01
    Relation: Human Molecular Genetics. 2004 Sep;13(17):1885-1892.
    Link to: http://dx.doi.org/10.1093/hmg/ddh196
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0964-6906&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000223720100006
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=4544345528
    Appears in Collections:[Chao A. Hsiung] Periodical Articles

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