English  |  正體中文  |  简体中文  |  Items with full text/Total items : 12145/12927 (94%)
Visitors : 916736      Online Users : 1525
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1705


    Title: Comparison of angiogenic factor levels in tumor drainage and peripheral venous blood from colorectal cancer patients
    Authors: Tien, YW;Chang, KJ;Chiu, YF;Huang, KW;Lee, PH
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: Background: The main objective of this study was to determine whether there was a correlation in the levels of various angiogenesis-related factors between the tumor drainage and peripheral venous blood and whether appraisal of angiogenic factor levels in the tumor drainage venous blood could provide better prognostic information for patients with colorectal cancer than assessment of the peripheral venous blood. Methods: Plasma levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor, and enclostatin were measured and compared in both tumor drainage and peripheral venous blood from 52 patients with colorectal cancer. Plasma levels of angiogenesis-related factors were also correlated with tumor stage and clinical outcomes. Results: The plasma endostatin level was significantly higher ill peripheral blood than in tumor drainage venous blood (P < .001). The plasma VEGF level was significantly correlated with plasma endostatin levels (P = .028 in tumor drainage venous blood and P = .002 in peripheral venous blood). Ill both tumor drainage and peripheral venous blood, the VEGF level (but not the basic fibroblast growth factor or enclostatin level) was significantly correlated with tumor stage and disease recurrence. However, in multivariate analysis, only plasma VEGF level in tumor drainage venous blood remained an independent predictor of disease recurrence. Conclusions: The plasma VEGF level in tumor drainage venous blood provided better prognostic information than that in peripheral venous blood. The plasma enclostatin level was paradoxically significantly higher in peripheral than in tumor drainage blood, and this strongly suggests additional sources of enclostatin in peripheral blood.
    Keywords: Oncology;Surgery
    Date: 2006-11
    Relation: Annals of Surgical Oncology. 2006 Nov;13(11):1357-1363.
    Link to: http://dx.doi.org/10.1245/s10434-006-9042-8
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1068-9265&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000242803000003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33751009666
    Appears in Collections:[邱燕楓] 期刊論文

    Files in This Item:

    File Description SizeFormat
    000242803000003.pdf199KbAdobe PDF555View/Open


    All items in NHRI are protected by copyright, with all rights reserved.

    Related Items in TAIR

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback