國家衛生研究院 NHRI:Item 3990099045/1701
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 909870      在线人数 : 829
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/1701


    题名: A comparison in association and linkage genome-wide scans for alcoholism susceptibility genes using single-nucleotide polymorphisms
    作者: Chiu, YF;Liu, SY;Tsai, YY
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: We conducted genome-wide linkage scans using both microsatellite and single-nucleotide polymorphism ( SNP) markers. Regions showing the strongest evidence of linkage to alcoholism susceptibility genes were identified. Haplotype analyses using a sliding-window approach for SNPs in these regions were performed. In addition, we performed a genome-wide association scan using SNP data. SNPs in these regions with evidence of association ( P <= 0.0001) were identified. We found that the general patterns for nonparametric linkage (NPL) scores from SNP and microsatellite genome scans are fairly consistent; however, the peaks of the NPL scores are mostly higher in the SNP-based scan than those using microsatellite markers, which might be located at different regions. Furthermore, SNPs identified from linkage screens were not so strongly associated with alcoholism ( the most significant SNP had a p-value of 0.030) as those identified from association genomic screening ( the most significant SNP had a p-value of 2.0 x 10(-8)).
    关键词: Genetics & Heredity
    日期: 2005-12-30
    關聯: BMC Genetics. 2005 Dec;6(Suppl. 1):Article number S89.
    Link to: http://dx.doi.org/10.1186/1471-2156-6-S1-S89
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000236103400089
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=30344438421
    显示于类别:[邱燕楓] 會議論文/會議摘要

    文件中的档案:

    档案 描述 大小格式浏览次数
    000236103400089.pdf382KbAdobe PDF685检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈