國家衛生研究院 NHRI:Item 3990099045/1696
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1696


    Title: Impact of apolipoprotein A5 polymorphisms on insulin sensitivity and beta-cell function
    Authors: Chiu, KC;Chiu, YF;Boyadjian, AA;Fernando, S;Kwan, C;Chuang, LM
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: Objectives: Alternation in lipid metabolism can affect both insulin sensitivity and beta-cell function. Apolipoprotein A5 (APOA5) is an important determinant of lipid metabolism. The impact of the APOA5 gene on insulin sensitivity and beta-cell function has not been examined. Methods: We examined the influence of 2 amino acid polymorphisms (V150M and G182C) in the APOA5 gene on insulin sensitivity and beta-cell function in 67 glucose-tolerant white subjects. Insulin sensitivity index (ISI) and first- and second-phase insulin responses (1stIR and 2ndIR) were assessed using a hyperglycemic clamp technique. Results: We identified 59 VV and 8 VM subjects, and none had either the GC or CC genotype. Although no association was found with fasting lipid profile and plasma glucose concentrations during oral glucose tolerance test, the V150M was associated with higher 1stIR ( P = 0.0010) and 2ndIR ( P = 0.0016) and lower ISI ( P = 0.0135). The associations of this polymorphism with 1stIR ( P = 0.0081) and 2ndIR ( P = 0.0087) were independent of sex, age, and body mass index, but not ISI. Conclusions: The V150M polymorphism had an independent influence on 1stIR and 2ndIR. Although the biologic consequence of this polymorphism remains to be determined, the V150M polymorphism in the APOA5 gene is a genetic marker for beta-cell function.
    Keywords: Gastroenterology & Hepatology
    Date: 2005-05
    Relation: Pancreas. 2005 May;30(4):328-332.
    Link to: http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?an=00006676-200505000-00007
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0885-3177&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000228704700007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=17844385850
    Appears in Collections:[Yen-Feng Chiu] Periodical Articles

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