國家衛生研究院 NHRI:Item 3990099045/16504
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/16504


    题名: Aminothiazole compounds as protein kinase inhibitors
    作者: Шинь, Чуань;Цзяан, Вэйр Торн;Тсай, Хуэй Цзэнь;Shin, Chuan;Tszyaan, Vejr Torn;Tsaj, Khuej Tszen
    贡献者: Institute of Biotechnology and Pharmaceutical Research;National Institute of Cancer Research
    摘要: FIELD: pharmaceutics. SUBSTANCE: invention relates to a compound of the formula (I) or to its pharmaceutically acceptable salt, where R1 is C1-6alkyl; X is NRa; Y is CRbRc or NRd, in which Rc is H, N(CH3)2, Rb, together with Ra, carbon atom related to Rb, and nitrogen atom related to Ra, is piperidinyl, and Rd, together with Ra and nitrogen atoms related to Rd and Ra, is piperazinyl; R2 is -CH2CH2Re or NRfRg, in which Re is H, halogen or ORh, and each of Rf and Rg is C1-6alkyl, Rh is H, and R3 is pyridyl or pyrimidinil. The invention also relates to a pharmaceutical composition for the treatment of cancer associated with tyrosine kinase, based on the compound of the formula (I). EFFECT: new compounds and a pharmaceutical composition based on them are obtained that can be used in medicine for the treatment of cancer. 13 cl, 1 tbl, 5 ex
    日期: 2022-05-23
    關聯: RU2772645/2022-05-23
    Link to: https://patentscope.wipo.int/search/en/detail.jsf?docId=RU325414149
    显示于类别:[蔣維棠] 專利
    [石全(2014-2017)] 專利
    [蔡慧珍] 專利

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