Parabens have been found in various environmental samples, particularly in indoor dust. Previous studies have linked exposure to parabens with thyroid dysfunction in pregnant women. We recruited 97 pregnant women and collected urine and blood samples at three visits in a medical center in Taiwan from 2013 to 2014. MeP and PrP were the major compounds in the second visit. A linear regression model was applied to investigate the effect of longitudinal paraben exposure on thyroid hormones. During the second visit, we found that exposure to all parabens was positively associated with Ln-TSH. Furthermore, exposure to EtP and BuP were both negatively associated with the Ln-TSH/FreeT4 ratio. Additionally, we observed that EtP and BuP were significantly associated with a decrease in Jostel's TSH index and SPINA-GT, while EtP and BuP were significantly associated with an increase in SPINA-GT. These findings emphasize the significance of unnegligible paraben exposure during pregnancy.
Date:
2024-06-07
Relation:
18th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2024 - Conference Program and Proceedings. 2024 Jun 07-11:858-860.
