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http://ir.nhri.org.tw/handle/3990099045/16432
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| Title: | Role of air pollution in development of hepatocellular carcinoma among chronic hepatitis B patients treated with nucleotide/nucleoside analogues |
| Authors: | Jang, TY;Zeng, YT;Liang, PC;Wu, CD;Wei, YJ;Tsai, PC;Hsu, PY;Hsieh, MY;Lin, YH;Hsieh, MH;Wang, CW;Yang, JF;Yeh, ML;Huang, CF;Chuang, WL;Huang, JF;Cheng, YY;Dai, CY;Chen, PC;Yu, ML |
| Contributors: | National Institute of Environmental Health Sciences;NHRI Graduate Student Program |
| Abstract: | Background and Aims: To investigate the association between air pollution and hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients treated with nucleotide/nucleoside analogues. Methods: We enrolled 1298 CHB patients treated with nucleotide/nucleoside analogues and analysed the incidence and risk factors for HCC. Daily estimates of air pollutants were estimated since the previous year from the enrolment date. Results: The annual incidence of HCC was 2.1/100 person-years after a follow-up period of over 4840.5 person-years. Factors with the strongest association with HCC development were liver cirrhosis (hazard ratio [HR]/95% confidence interval [CI]: 3.00/1.55-5.81; p = 0.001), male sex (2.98/1.51-5.90; p = 0.02), body mass index (1.11/1.04-1.18; p = 0.002) and age (1.06/1.04-1.09; p < 0.001). Among patients with cirrhosis, the factors associated with HCC development were male sex (HR/95% CI: 2.10/1.00-4.25; p = 0.04) and NO2 (per one-unit increment, parts per billion; 1.07/1.01-1.13; p = 0.01). Moreover, patients with the highest quartile of annual NO2 exposure had more than a three-fold risk of HCC than those with the lowest quartile of annual exposure (HR/95% CI: 3.26/1.34-7.93; p = 0.01). Among patients without cirrhosis, the strongest factors associated with HCC development were male sex (HR/95% CI: 5.86/1.79-19.23; p = 0.004), age (1.12/1.07-1.17; p < 0.001) and platelet count (0.99/0.98-1.00; p = 0.04). Conclusions: Air pollution influences HCC development in CHB patients who receive nucleotide/nucleoside analogue therapy. Long-term NO2 exposure might accelerate HCC development in CHB patients with cirrhosis receiving nucleotide/nucleoside analogue treatment. |
| Date: | 2024-11-26 |
| Relation: | Liver International. 2024 Nov 26;Article in Press. |
| Link to: | http://dx.doi.org/10.1111/liv.16149 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:001363855700001 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85210153918 |
| Appears in Collections: | [陳保中] 期刊論文
[其他] 期刊論文
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| ISI001363855700001.pdf | | 387Kb | Adobe PDF | 3 | View/Open |
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