國家衛生研究院 NHRI:Item 3990099045/1642
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1642


    Title: Chinese herbs as immunomodulators and potential disease-modifying antirheumatic drugs in autoimmune disorders
    Authors: Ho, LJ;Lai, JH
    Contributors: Division of Gerontology Research
    Abstract: Autoimmune diseases arc a group of illnesses With Multiple organ involvement. The prototype of this group of disorders is rheumatoid arthritis (RA) that aside from systemic organ involvement mainly presents with progressive destruction of many Joints. Both activation and defective apoptosis of immune effector cells like T and B lymphocytes and macrophages play critical roles in the pathogenesis of autoimmune disorders. Current therapy for autoimmune diseases recommends a combination of several disease-modifying antirheumatic drugs (DMARDs) that preserve different immunomodulatory mechanisms. Because of limited success in prevention of RA joint destruction for currently available DMARDs. the development of more effective and less toxic DMARDs has been one of the major goals for pharmaceutical companies. The introduction of leflunomide and anti-tumor necrosis factor alpha therapies to the market recently serves as examples. In this context, the experience from ancient Chinese medicine gives all alternative consideration looking for potential DMARDs. Two commonly prescribed Chinese antirheumatic herbs arc Tripterygium wilfordii hook f (TWHf) and tetrandrine (Tet) that preserve both anti-inflammatory and immunosuppressive effects. Importantly. the TWHf- or Tet-mediated immunomodulatory mechanisms arc evidently different from the known DMARDs. The synergistic effects have also been demonstrated between these two Chinese antirheumatic herbs and DMARDs like FK506, cyclosporin and possibly chloroquine. Another potential Chinese herb for this consideration is Ginkgo biloba. This review summarizes evidence-based in vivo and in vitro studies oil Chinese herbs as immunomodulators and potential DMARDs.
    Keywords: Biochemistry & Molecular Biology;Pharmacology & Pharmacy
    Date: 2004-04
    Relation: Current Drug Metabolism. 2004 Apr;5(2):181-192.
    Link to: http://dx.doi.org/10.2174/1389200043489081
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1389-2002&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000220855200005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=1942485431
    Appears in Collections:[Ling-Jun Ho] Periodical Articles

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