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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/16414
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| Title: | Genetic variants in mitochondria contribute the risk of familial lung cancer |
| Authors: | Yang, S;Chang, Y;Wu, W;Yen, C;Chen, Y;Chen, C;Huang, W;Chen, H |
| Contributors: | Institute of Molecular and Genomic Medicine |
| Abstract: | Background: Family history, especially among non-smoking females, is a significant risk factor for lung cancer. Our previous research indicated that individuals with a maternal family history of lung cancer face a notably higher lung cancer risk than those without such a family history. Mitochondrial DNA is typically inherited from the mother. Therefore, we aimed to explore whether mitochondria variants might contribute to the susceptibily of lung cancer. Methods: In this study, 741 non-smoking individuals with a family history of lung cancer participated, and 4.7% were diagnosed with lung cancer. We extracted and sequenced mitochondrial DNA from peripheral blood samples. We identified germline variants associated with maternal inheritance by comparing mitochondrial variant frequencies in individuals with or without a family history of maternal lung cancer and with or without a lung cancer diagnosis. Candidate varaints were furthur vailidated in 57 subjects from 10 families and in an independent cohort consisting of 962 cases and 952 controls. Results: In the exploratory cohort, 8 mitochondria variants assocaited with materal interiance were identified, and subjects with family history of lung cancer in their mothers and a diagnosis of lung cancer had higher carrier frequencies of these variants compared to others(p<0.05). Among 57 subjects from 10 families, the results also demostrated that 6 out of 8 variants were transmitted from mothers to their children. In the independent case-control study, 3 variants were remains significantly associated with lung cancer, with odds ratio were ranging from 1.47 to 1.69. Conclusions: Mitochondria variants contribute to the susceptibility of lung cancer, and help explain why family history is an implortant risk factor, especially for invididual with a family history of materanl relatives with lung cancer. These variants can potentially serve as biomarkers for identifying high-risk individuals, facilitating early detection. |
| Date: | 2024-10 |
| Relation: | Annals of Oncology. 2024 Oct;35(Suppl. 3):S1359-S1360. |
| Link to: | http://dx.doi.org/10.1016/j.annonc.2024.07.622 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:001345709300210 |
| Appears in Collections: | [張雅媗] 會議論文/會議摘要
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| ISI001345709300210.pdf | | 134Kb | Adobe PDF | 6 | View/Open |
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