國家衛生研究院 NHRI:Item 3990099045/1638
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    题名: Carvedilol differentially regulates cytokine production from activated human peripheral blood mononuclear cells
    作者: Yang, SP;Ho, LJ;Cheng, SM;Hsu, YL;Tsao, TP;Chang, DM;Lai, JH
    贡献者: Division of Gerontology Research
    摘要: Chronic inflammation is one of the important mechanisms involved in atherosclerosis formation. The activated monocytes and their secreted cytokines contribute significantly to this inflammatory process. Here we examined the effects of carvedilol, a recently introduced cardioprotective alpha-1- and beta-receptor blocker, on cytokine production from various stimuli-activated human immune effector cells. By ELISA analysis, we showed that carvedilol inhibited interferon-gamma (IFN-gamma), but enhanced interleukin (IL)-12 production in phytohemagglutinin (PHA)- and concanavalin A (ConA)-stimulated human peripheral blood mononuclear cells (PBMCs). The production of tumor necrosis factor-alpha (TNF-alpha) was marginally affected. When purified monocytes were examined, we observed the consistent up-regulation of IL-12 production while both IL-10 and TNF-alpha were unaffected or marginally downregulated, respectively, by carvedilol. In agreement with the observation in monocytes, the production of IL-12 from activated macrophages was also up-regulated by carvedilol. We concluded that carvedilol might mediate its therapeutic effects through differentially regulating cytokine production from activated mononuclear cells, including at least monocytes and macrophages.
    关键词: Cardiac & Cardiovascular Systems;Pharmacology & Pharmacy
    日期: 2004-05
    關聯: Cardiovascular Drugs and Therapy. 2004 May;18(3):183-188.
    Link to: http://dx.doi.org/10.1023/B:CARD.0000033638.37830.f7
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0920-3206&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000222359000003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=3142729922
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