國家衛生研究院 NHRI:Item 3990099045/16294
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12190/12972 (94%)
造访人次 : 1075732      在线人数 : 592
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/16294


    题名: Differentiating the Abeta42 aggregation states via intrinsic tyrosine fluorescence spectrum
    其它题名: Differentiating the Aβ42 aggregation states via intrinsic tyrosine fluorescence spectrum
    作者: Yang, CT;Cheng, PY;Tsao, YC;Chen, HY;Wu, TH;Kao, TL;Kung, LC;Lin, SY;Chu, LK;Chiu, CC
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Aggregation of amyloid β-peptide (Aβ) into β-sheet-rich fibrils is central to the development of Alzheimer's disease, with Aβ42 more prone to aggregation over Aβ40. Using the intrinsic tyrosine fluorescence spectrum, we show that Aβ42 exhibits a biphasic fluorescence pattern featuring a broad band and a narrow one, distinct from Aβ40 and dissolved tyrosine. Molecular dynamics simulations highlighted the differences in tyrosine's rotamer populations and dynamics between dissolved and aggregated amyloids. Fibrillar Aβ42 shows slower, more uniform tyrosine rotations, corresponding to the narrower fluorescence band. This approach offers a rapid means to differentiate Aβ42 aggregates, benefiting Aβ-related research.
    日期: 2025-01
    關聯: Chemical Physics Letters. 2025 Jan;858:Article number 141739.
    Link to: http://dx.doi.org/10.1016/j.cplett.2024.141739
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0009-2614&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001358283900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85208667817
    显示于类别:[林淑宜] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    SCP85208667817.pdf2550KbAdobe PDF11检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈