國家衛生研究院 NHRI:Item 3990099045/16268
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    题名: Beta-d-Ribofuranose as a core with a phosphodiester moiety as the enzyme recognition site for codrug development
    其它题名: β-d-Ribofuranose as a Core with a Phosphodiester Moiety as the Enzyme Recognition Site for Codrug Development
    作者: Hwu, JR;Panja, A;Tsay, SC;Huang, WC;Lin, SY;Yeh, CS;Su, WC;Yang, LX;Shieh, DB
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: An ideal codrug design should be able to control drug release, offer selectivity during drug delivery, and break down into non-toxic fragments after biodegradation. Our design incorporates d-ribofuranose as the core, with carbamate and carbonate groups as linking joints, a phosphodiester moiety as an enzyme recognition site, and lenalidomide and paclitaxel as the constituent drugs. The codrug synthesis involves seven steps with a 33% overall yield. The target codrug increases its water solubility 685 times versus paclitaxel.
    日期: 2024-11-13
    關聯: Organic letters. 2024 Nov 13;Article in Press.
    Link to: http://dx.doi.org/10.1021/acs.orglett.4c03662
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1523-7060&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001354980900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85209554588
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