國家衛生研究院 NHRI:Item 3990099045/16242
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/16242


    Title: Association of bone turnover markers and craving reduction in patients with alcohol use disorder during withdrawal: Exploring the role of bone-brain axis
    Authors: Tsao, HM;Huang, MC;Liu, TH;Chang, HM;Chung, RH;Kuo, HW;Chen, ACH;Yang, RS;Liu, YL
    Contributors: Center for Neuropsychiatric Research;Institute of Population Health Sciences
    Abstract: BACKGROUND: Alcohol use disorder (AUD) is associated with imbalanced bone turnover and psychological symptoms, but the relationship between bone and brain remains unclear. The study analyzed serum levels of a bone formation marker, procollagen type 1 N-terminal propeptide (P1NP), and bone resorption marker, C-terminal telopeptide of type I collagen (CTX-1), in AUD patients before and after 2 weeks of alcohol withdrawal and investigated their correlation with psychological symptoms. METHODS: Ninety patients with AUD and 117 healthy controls were recruited. P1NP and CTX-1 levels were measured using Enzyme-Linked Immunosorbent Assay. The Penn Alcohol Craving Scale (PACS), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) were assessed in the AUD group at baseline, week 1, and week 2 of withdrawal. RESULTS: Baseline CTX-1 levels, along with the CTX-1/P1NP and P1NP/CTX-1 ratio, were higher in the AUD group than controls. Over the 2-week withdrawal, PACS, BDI, and BAI scores demonstrated significant reductions. P1NP (p < 0.001) and P1NP/CTX-1 ratio increased (p < 0.001), while CTX-1/P1NP ratio decreased (p < 0.001), indicating a propensity toward bone formation. Univariate analysis revealed that reductions in PACS, BDI, and BAI scores during withdrawal correlated with increased P1NP levels and decreased CTX-1/P1NP ratios. However, multivariate analysis indicated that only PACS score reductions correlated with these changes. CONCLUSIONS: Bone metabolism shifted toward increased bone formation and decreased bone resorption during 2-week alcohol withdrawal. The correlation between improvements in bone turnover markers and reduction in craving scores during withdrawal supports the concept of the bone-brain axis.
    Date: 2024-10-30
    Relation: Alcohol, Clinical and Experimental Research. 2024 Oct 30;Article in Press.
    Link to: http://dx.doi.org/10.1111/acer.15472
    Appears in Collections:[Yu-Li Liu] Periodical Articles
    [Ren-Hua Chung] Periodical Articles

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