Loading...
|
Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/16221
|
| Title: | Plasma leptin levels are lower in females, but not males, with ketamine use disorder |
| Authors: | Huang, MC;Chiang, LJ;Chien, WH;Liu, TH;Chen, CH;Liu, YL |
| Contributors: | Center for Neuropsychiatric Research |
| Abstract: | Background: Ketamine has emerged as a prominent substance of misuse. Leptin, an adipocyte-derived polypeptide hormone, has been implicated in the development of addiction. Sex-specific changes in leptin levels have been demonstrated following acute ketamine administration; the persistence of long-term ketamine use on leptin levels is uncertain. Objectives: To assess the sex-difference of leptin levels, and their persistence, in individuals with ketamine use disorder (KUD) compared to healthy controls. Methods: Plasma leptin levels were measured in 62 healthy controls (37 males, 25 females) and 68 participants with KUD (50 males, 18 females) on the first day (baseline) and after 1 and 2 weeks of abstinence. As leptin levels are affected by body mass index (BMI), BMI-adjusted leptin (leptin/BMI ratio) was also examined. Mixed model for repeated measures was used to examine changes after ketamine abstinence. Results: Compared to same-sex controls, female, but not male, participants with KUD demonstrated lower leptin levels and leptin/BMI ratio at baseline, week 1, and week 2 (leptin levels: p = .001, 0.006 and 0.032, respectively; leptin/BMI ratio: p = .004, 0.022, and 0.09, respectively). Repeated measures showed that leptin levels and the leptin/BMI ratio increased after 2 weeks of abstinence in male participants with KUD (p = .002 and 0.011, respectively), but females did not show such an increase (p > .05). Conclusions: Sex-specific differences were observed in leptin levels and the leptin/BMI ratio in individuals with KUD compared to controls. Lower leptin levels in females with KUD persisted after 2 weeks of abstinence. |
| Date: | 2024-10-21 |
| Relation: | American Journal of Drug and Alcohol Abuse. 2024 Oct 21;Article in Press. |
| Link to: | http://dx.doi.org/10.1080/00952990.2024.2394963 |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:001339832900001 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85207274788 |
| Appears in Collections: | [劉玉麗] 期刊論文
|
Files in This Item:
| File |
Description |
Size | Format | |
|---|
| ISI001339832900001.pdf | | 753Kb | Adobe PDF | 21 | View/Open |
|
All items in NHRI are protected by copyright, with all rights reserved.
|
